Personnel
Alexei Kostygov, Ph.D., postdoctoral researcher
Education: Zoological Institute, Russian Academy of Sciences, St. Petersburg, Russia. Ph.D. 2013
Publications
Kostygov, A.Y., Grybchuk-Ieremenko, A., Malysheva, M., Frolov, A., Yurchenko, V. Molecular revision of the genus Wallaceina. Protist, 2014, 165: 594-604. PMID: 25113831
Chistyakova, L., Kostygov, A.Y., Kornilova, O., Yurchenko, V. Reisolation and redescription of Balantidium duodeni Stein, 1867 (Litostomatea, Trichostomatia). Parasitol. Res., 2014, 113: 4207–4215. PMID: 25185665
Votýpka, J.*, Kostygov, A.Y.*, Kraeva, N., Grybchuk-Ieremenko, A., Tesařová, M., Grybchuk, D., Lukeš, J., Yurchenko, V. Kentomonas gen. n., a new genus of endosymbiont-containing trypanosomatids of Strigomonadinae subfam. n. Protist, 2014, 165: 825-838. * Equal contribution. PMID: 25460233
Grybchuk-Ieremenko, A., Losev, A., Kostygov, A.Y., Lukeš, J., Yurchenko, V. High prevalence of trypanosome co-infections in freshwater fishes. Folia Parasitol., 2014, 61: 495-504. PMID: 25651690
Losev, A., Grybchuk-Ieremenko, A., Kostygov, A.Y., Lukeš, J., Yurchenko, V. Host specificity, pathogenicity and mixed infections of trypanoplasms from freshwater fishes. Parasitol. Res., 2015, 114:1071–1078. PMID: 25544706
Kraeva, N., Butenko, A., Hlaváčová, J., Kostygov, A.Y., Myškova, J., Grybchuk, D., Leštinová, T., Votýpka, J., Volf, P., Opperdoes, F., Flegontov, P., Lukeš, J., Yurchenko, V. Leptomonas seymouri: adaptations to the dixenous life cycle analyzed by genome sequencing, transcriptome profiling and co-infection with Leishmania donovani. PLoS Path., 2015, 11(8): e1005127. PMID: 226317207
d'Avila-Levy, C., Boucinha, C., Kostygov, A.Y., Santos, H. L. C., Morelli, K. A., Grybchuk-Ieremenko, A., Duval, L., Votýpka, J., Yurchenko, V., Grellier, P., Lukeš, J. Exploring environmental diversity of kinetoplastid flagellates in the high-throughput DNA sequencing era (Review). Mem Inst Oswaldo Cruz, 2015, 110(8): 956-965. PMID: 26602872
Frolov, A., Malysheva, M., Yurchenko, V., Kostygov, A.Y.* Back to monoxeny: Phytomonas nordicus descended from dixenous plant parasites. Eur. J. Protistol., 2016, 52 (1):1-10. * Correspondent author. PMID: 26555733
Yurchenko, V., Kostygov, A.Y., Havlová, J., Grybchuk-Ieremenko, A., Ševčíková, T., Lukeš, J., Ševčík, J., Votýpka, J. Diversity of trypanosomatids in cockroaches and the description of Herpetomonas tarakana sp. n. J. Euk. Microbiol., 2016, 63: 198-209. PMID: 26352484
Kostygov, A.Y.*, Dobáková, E.*, Grybchuk-Ieremenko, A.*, Váhala, D., Maslov, D., Votýpka, J., Lukeš, J., Yurchenko, V. Novel trypanosomatid – bacterium association: evolution of endosymbiosis in action. mBio, 2016, 7(2): e01985-15. * Equal contribution. PMID: 26980834
Flegontov, P., Butenko, A., Firsov. S., Kraeva, N., Eliáš, M., Field, M., Filatov, D., Flegontova, O., Gerasimov, E., Hlaváčová, J., Ishemgulova, A., Jackson, A., Kelly, S., Kostygov, A.Y., Logacheva, M., Maslov, D., Opperdoes, F., O'Reilly, A., Sádlová, J., Ševčíková, T., Venkatesh, D., Vlček, Č., Volf, P., Votýpka, J., Záhonová, K., Yurchenko, V., Lukeš, J. Genome of Leptomonas pyrrhocoris: a high-quality reference for monoxenous trypanosomatids and new insights into evolution of Leishmania. Sci. Rep., 2016, 6: 23704. PMID: 27021793
Záhonová, K.*, Kostygov, A.Y.*, Ševčíková, T., Yurchenko, V., Eliáš, M. An unprecedented non-canonical nuclear genetic code with all three termination codons reassigned as sense codons. Curr. Biol., 2016, 26: 2364-2369. * Equal contribution. PMID: 27593378
Kraeva, N., Horáková, E., Kostygov, A.Y., Kořený, L., Butenko, A., Yurchenko, V., Lukeš, J. Catalase in Leishmaniinae: with me or against me? Infect. Genet. Evol., 2017, 50: 121-127. PMID: 27381333
Frolov, A., Malysheva, M., Ganyukova, A., Yurchenko, V., Kostygov, A.Y.* Life cycle of Blastocrithidia papi sp. n. (Kinetoplastea, Trypanosomatidae) in Pyrrhocoris apterus (Hemiptera, Pyrrhocoridae). Eur. J. Protistol., 2017, 57: 85-98. * Correspondent author. PMID: 28073072
Ishemgulova, A., Butenko, A., Kortišová, L., Boucinha, C., Grybchuk-Ieremenko, A., Morelli, K.A., Tesařová, M., Kraeva, N., Grybchuk, D., Pánek, T., Flegontov, P., Lukeš, J., Votýpka, J., Galvão Pavan, M., Opperdoes, F.R., Spodareva, V., d'Avila-Levy, C., Kostygov, A.Y.*, Yurchenko, V.* Molecular mechanisms of thermal resistance of the insect trypanosomatid Crithidia thermophila. PLoS One, 2017, 12(3): e0174165. * Co-correspondent authors. PMID: 28328988
Kostygov, A.Y., Yurchenko, V. Revised classification of the subfamily Leishmaniinae (Trypanosomatidae). Folia Parasitol., 2017, 64: 020. PMID: 28783029
Ishemgulova, A., Kraeva, N., Hlaváčová, J., Zimmer, S., Butenko, A., Podešvová, L., Leštinová, T., Lukeš, J., Kostygov, A.Y., Votýpka, J., Volf, P., Yurchenko, V. A putative ATP/GTP binding protein affects Leishmania mexicana growth in insect vectors and vertebrate hosts. PLoS Negl. Trop. Dis., 2017, 11(7): e0005782. PMID: 28742133
Kostygov, A.Y.*, Butenko, A.*, Nenarokova, A., Tashyreva, D., Flegontov, P., Lukeš, J., Yurchenko, V. Genome of Ca. Pandoraea novymonadis, an endosymbiotic bacterium of the trypanosomatid Novymonas esmeraldas. Front. Microbiol., 2017, 8: 1940. * Equal contribution. PMID: 29046673.
Butenko, A., da Silva Vieira, T., Frolov, A.O., Opperdoes, F.R., Soares, R.P., Kostygov, A.Y., Lukeš, J., Yurchenko, V. Leptomonas pyrrhocoris: genomic insight into parasite's physiology. Curr. Genomics, 2018, 19(2): 150-156. PMID: 29491743
Grybchuk, D., Akopyants. N.S., Kostygov, A.Y., Konovalovas, A., Lye, L.-F., Dobson, D.E., Zangger, H., Fasel. N., Butenko, A., Frolov. A.O., Votýpka, J., d'Avila-Levy, C.M., Kulich, P., Moravcová, J., Plevka, P., Rogozin, I.B., Serva, S., Lukeš, J., Beverley, S.M., Yurchenko, V. Viral discovery and diversity in trypanosomatid protozoa with a focus on relatives of the human parasite Leishmania. Proc. Natl. Acad. Sci. USA, 2018, 115(3): E506-E515. PMID: 29284754
Grybchuk, D., Kostygov, A.Y., Macedo, D.H., d'Avila-Levy, C.M., Yurchenko, V. RNA viruses in trypanosomatid parasites: a historical overview (Review). Mem. Inst. Oswaldo Cruz, 2018, 113(4): e170487. PMID: 29513877
Silva, F., Kostygov, A.Y., Spodareva, V., Butenko, A., Tossou, R., Lukeš, J., Yurchenko, V., Alves, J. The reduced genome of Candidatus Kinetoplastibacterium sorsogonicusi, the endosymbiont of Kentomonas sorsogonicus (Trypanosomatidae): loss of the heme synthesis pathway. Parasitology, 2018, 145(10): 1287-1293. PMID: 29642956
Spodareva, V., Grybchuk-Ieremenko, A., Losev, A., Votýpka, J., Lukeš, J., Yurchenko, V.*, Kostygov, A.Y.* Diversity and evolution of anuran trypanosomes: insights from the study of European species. Parasit. Vectors, 2018, 11: 447. * Co-correspondent authors. PMID: 30071897
Frolov, A., Malysheva, M., Ganyukova, A., Yurchenko, V., Kostygov, A.Y.* Obligate development of Blastocrithidia papi (Trypanosomatidae) in the Malpighian tubules of Pyrrhocoris apterus (Hemiptera) and coordination of host-parasite life cycles. PLoS One, 2018, 13(9): e0204467. * Correspondent author. PMID: 30261003
Grybchuk, D., Kostygov, A.Y., Macedo, D.H., Votýpka, J., Lukeš, J., Yurchenko, V. RNA viruses in Blechomonas (Trypanosomatidae) and evolution of Leishmaniavirus. mBio, 2018, 9(5): e01932-18. PMID: 30327446
Maslov, D.A., Opperdoes, F.R., Kostygov, A.Y., Hashimi, H., Lukeš, J., Yurchenko, V. Recent advances in trypanosomatid research: genome organization, expression, metabolism, taxonomy, and evolution (Review). Parasitology, 2019, 146(1): 1-27. PMID: 29898792
Kostygov, A.Y., Butenko, A., Yurchenko, V. On monoxenous trypanosomatids from lesions of immunocompetent patients with suspected cutaneous leishmaniasis in Iran. Trop. Med. Int. Health, 2019, 24(1): 127-128. PMID: 30307678
Frolov, A.O, Malysheva, M.N., Ganyukova, A.I., Spodareva, V.V., Yurchenko, V., Kostygov, A.Y.* Development of Phytomonas lipae sp. n. (Kinetoplastea: Trypanosomatidae) in the true bug Coreus marginatus (Heteroptera: Coreidae) and insights into the evolution of life cycles in the genus Phytomonas. PLoS One, 2019, 14(4): e0214484. * Correspondent author. PMID: 30943229
Bianchi, C., Kostygov, A.Y., Kraeva, N., Záhonová, K., Horáková, E., Sobotka, R., Lukeš, J., Yurchenko, V. An enigmatic catalase of Blastocrithidia. Mol. Biohem. Parasitol., 2019, 232: 111199. PMID: 31276694
Butenko, A., Kostygov, A.Y., Sádlová, J., Kleschenko, Y., Bečvář, T., Podešvová, L., Macedo, D.H., Žihala, D., Lukeš, J., Bates, P.A., Volf, P., Opperdoes, F.R., Yurchenko, V. Comparative genomics of Leishmania (Mundinia). BMC Genomics, 2019, 20(1): 726. PMID: 31601168
Kraeva, N., Leštinová, T., Ishemgulova, A., Majerová, K., Butenko, A., Vaselek, S., Bespyatykh, J., Charyyeva, A., Spitzová, T., Kostygov, A.Y., Lukeš, J., Volf, P., Votýpka, J., Yurchenko, V. LmxM.22.0250-encoded dual specificity protein/lipid phosphatase impairs Leishmania mexicana virulence in vitro. Pathogens, 2019, 8: E241. PMID: 31744234
Králová, J., Grybchuk-Ieremenko, A., Votýpka, J., Novotný, V., Kment, P., Lukeš, J., Yurchenko, V.*, Kostygov, A.Y.* Insect trypanosomatids in Papua New Guinea: high endemism and diversity. Int. J. Parasitol., 2109, 49: 1075-1086. * Co-correspondent authors. PMID: 31734337
Frolov, A.O., Malysheva, M.N., Ganyukova, A.I., Spodareva, V.V., Králová, J., Yurchenko, V., Kostygov, A.Y.* If host is refractory, insistent parasite goes berserk: trypanosomatid Blastocrithidia raabei in the true bug Coreus marginatus. PLoS One, 2020, 15(1): e0227832. * Correspondent author. PMID: 31945116
Grybchuk, D., Macedo, D.H., Kleschenko, Y., Kraeva, N., Lukashev, A.N., Bates, P.A., Kulich, P., Leštinová, T., Volf, P., Kostygov, A.Y.*, Yurchenko, V.* The first non-LRV RNA virus in Leishmania. Viruses, 2020, 12: 168. * Co-correspondent authors. PMID: 32024293
Ganyukova, A.I., Frolov, A.O., Malysheva, M.N., Spodareva, V.V., Yurchenko, V., Kostygov, A.Y.* A novel endosymbiont-containing trypanosomatid Phytomonas borealis sp. n. from the predatory bug Picromerus bidens (Heteroptera, Pentatomidae). Folia Parasitol., 2020, 67: 004. * Correspondent author. PMID: 32350156
Kostygov, A.Y.*, Frolov, A.O., Malysheva, M.N., Ganyukova, A.I., Chistyakova, L.V., Tashyreva, D., Tesařová, M., Spodareva, V.V., Režnarová, J., Macedo, D., Butenko, A., d’Avila-Levy, C.M., Lukeš, J., Yurchenko, V. Vickermania gen. nov., trypanosomatids that use two joined flagella to resist midgut peristaltic flow within the fly host. BMC Biol., 2020, 18: 187. * Correspondent author. PMID: 33267865
Kostygov, A.Y., Karnkowska, A., Votýpka, J., Tashyreva, D., Maciszewski, K., Yurchenko, V., Lukeš, J. Euglenozoa: taxonomy, diversity and ecology, symbioses and viruses. Open Bio., 2021, 11: 200407. PMID: 33715388
Charyyeva, A., Çetinkaya, Ü., Özkan. B., Şahin, S., Yaprak, N., Şahin, I., Yurchenko, V.*, Kostygov, A.Y.* Genetic diversity of Leishmania tropica: unexpectedly complex distribution pattern. Acta Trop., 2021, 218: 105888. * Co-correspondent authors. PMID: 33713626
Albanaz, A.T.S.; Gerasimov, E.S.; Shaw, J.J.; Sádlová, J.; Lukeš, J.; Volf, P.; Opperdoes, F.R.; Kostygov, A.Y.; Butenko, A.; Yurchenko, V. Genome analysis of Endotrypanum and Porcisia spp., closest phylogenetic relatives of Leishmania, highlights the role of amastins in shaping pathogenicity. Genes. 2021, 12(3): 444. PMID: 33804709
Frolov, A.O.*, Kostygov,A.Y.*, Yurchenko, V.* Development of monoxenous trypanosomatids and phytomonads in insects. Trends Parasitol., 2021, 37(6): 538-551. * Co-correspondent authors. PMID: 33714646
Skalický, T., Alves, J.M.P., Morais, A.C., Režnarová, J., Butenko, A., Lukeš, J., Serrano, M.G., Buck, G.A., Teixeira, M.M.G., Camargo, E.P., Sanders, M., Cotton, J.A., Yurchenko, V., Kostygov,A.Y.* Endosymbiont capture, a repeated process of endosymbiont transfer with replacement in trypanosomatids Angomonas spp. Pathogens, 2021, 10: 702. * Correspondent author. PMID: 34200026
Kostygov,A.Y.*, Alves, J.M.P.*, Yurchenko, V.* Editorial: symbioses between protists and bacteria/archaea. Front. Microbiol., 2021, 12: 709184. * Co-correspondent authors. PMID: 34394058
Zakharova, A., Saura, A., Butenko, A., Podešvová, L., Warmusová, S., Kostygov,A.Y., Nenarokova, A., Lukeš, J., Opperdoes, F.R., Yurchenko, V. A new model trypanosomatid Novymonas esmeraldas: genomic perception of its "Candidatus Pandoraea novymonadis" endosymbiont. mBio, 2021, 12(4): e01606-21. PMID: 34399629
Yurchenko, V.*, Butenko, A., Kostygov, A.Y.* Genomics of Trypanosomatidae: where we stand and what needs to be done? Pathogens, 2021, 10: 1124. * Co-correspondent authors. PMID: 34578156
Kostygov, A.Y.*; Grybchuk, D., Kleschenko, Y., Chistyakov, D.S., Lukashev, A.N., Gerasimov, E.S., Yurchenko, V.* Analyses of Leishmania-LRV co-phylogenetic patterns and evolutionary variability of viral proteins. Viruses, 2021, 13(11): 2305. * Co-correspondent authors. PMID: 34835111
Chmelová, L’., Bianchi, C., Albanaz, A.T.S., Režnarová, J., Wheeler, R., Kostygov, A.Y., Kraeva, N., Yurchenko, V. Comparative analysis of three trypanosomatid catalases of different origin. Antioxidants, 2022, 11: 46. PMID: 35052550
Kostygov, A.Y.*, Frolov, A.O., Malysheva, M.N., Ganyukova, A.I., Drachko, D., Yurchenko, V., Agasoy, V.V. Development of two species of the Trypanosoma theileri complex in tabanids. Parasit. Vectors, 2022, 15: 95. * Correspondent author. PMID: 35313955
Saura, A., Zakharova, A., Klocek, D., Gerasimov, E.S., Butenko, A., Macedo, D.H., Servienė, E., Zagirova, D., Meshcheryakova, A., Rogozin, I.B., Serva, S., Kostygov, A.Y.*, Yurchenko, V.* Elimination of LRVs elicits different responses in Leishmania spp. mSphere, 2022, 7(4): e00335-22. * Co-correspondent authors. PMID: 35943162
Kostygov, A.Y.*, Malysheva, M.N., Ganyukova, A.I., Razygraev, A.V., Drachko, D.O., Yurchenko, V., Agasoi, V.V., Frolov, A.O. The roles of mosquitoes in the circulation of monoxenous trypanosomatids in temperate climates. Pathogens, 2022, 11: 1326. * Correspondent author. PMID: 36422578
Magri, A.*, Bianchi, C., Chmelová, L′., Caffara, M., Galuppi, R., Fioravanti, M., Yurchenko, V.*, Kostygov, A.Y.* Roe deer (Capreolus capreolus) are a novel potential reservoir for human visceral leishmaniasis in the Emilia-Romagna region of Northeastern Italy. Int. J. Parasitol., 2022, 52(12): 745-750. * Co-correspondent authors. PMID: 36265672
Natalia Kraeva, Ph.D., postdoctoral researcher
Education: Ostravská Univerzita, Ostrava, Czech Republic. Ph.D. 2017
Publications
Votýpka, J., Suková, E., Kraeva, N., Ishemgulova, A., Duží, I., Lukeš, J., Yurchenko, V. Diversity of trypanosomatids (Kinetoplastea: Trypanosomatidae) parasitizing fleas (Insecta: Siphonaptera) and description of a new genus Blechomonas gen. n. Protist, 2013, 164: 763-781. PMID: 24113136
Yurchenko, V., Votýpka, J., Tesařová, M., Klepetková, H., Kraeva, N., Jirků, M., Lukeš, J. Ultrastructure and molecular phylogeny of four new species of monoxenous trypanosomatids from flies (Diptera: Brachycera) with redefinition of the genus Wallaceina. Folia Parasitol., 2014, 61: 97-112. PMID: 24822316
Votýpka, J., Kostygov, A., Kraeva, N., Grybchuk-Ieremenko, A., Tesařová, M., Grybchuk, D., Lukeš, J., Yurchenko, V. Kentomonas gen. n., a new genus of endosymbiont-containing trypanosomatids of Strigomonadinae subfam. n. Protist, 2014, 165: 825-838. PMID: 25460233
Kraeva, N., Ishemgulova, A., Lukeš, J., Yurchenko, V. Tetracycline-inducible gene expression system in Leishmania mexicana. Mol. Biochem. Parasitol., 2014, 198: 11-13. PMID: 25461484
Kraeva, N., Butenko, A., Hlaváčová, J., Kostygov, A., Myškova, J., Grybchuk, D., Leštinová, T., Votýpka, J., Volf, P., Opperdoes, F., Flegontov, P., Lukeš, J., Yurchenko, V. Leptomonas seymouri: adaptations to the dixenous life cycle analyzed by genome sequencing, transcriptome profiling and co-infection with Leishmania donovani. PLoS Path., 2015, 11(8): e1005127. PMID: 226317207
Kozminsky, E., Kraeva, N., Ishemgulova, A., Dobáková, E., Lukeš, J., Kment, P., Yurchenko, V., Votýpka, J., Maslov, D. Host-specificity of monoxenous trypanosomatids: statistical analysis of the distribution and transmission patterns of the parasites from Neotropical Heteroptera. Protist, 2015, 166(5): 551-568. PMID: 26466163
Flegontov, P., Butenko, A., Firsov. S., Kraeva, N., Eliáš, M., Field, M., Filatov, D., Flegontova, O., Gerasimov, E., Hlaváčová, J., Ishemgulova, A., Jackson, A., Kelly, S., Kostygov. A., Logacheva, M., Maslov, D., Opperdoes, F., O'Reilly, A., Sádlová, J., Ševčíková, T., Venkatesh, D., Vlček, Č., Volf, P., Votýpka, J., Záhonová, K., Yurchenko, V., Lukeš, J. Genome of Leptomonas pyrrhocoris: a high-quality reference for monoxenous trypanosomatids and new insights into evolution of Leishmania. Sci. Rep., 2016, 6: 23704. PMID: 27021793
Ishemgulova, A., Kraeva, N., Faktorová, D., Podešvová, L., Lukeš, J., Yurchenko, V. T7 polymerase-driven transcription is downregulated in metacyclic promastigote and amastigote Leishmania mexicana. Folia Parasitol., 2016, 63: 016. PMID: 27311571
Kraeva, N.*, Horáková, E.*, Kostygov, A., Kořený, L., Butenko, A., Yurchenko, V., Lukeš, J. Catalase in Leishmaniinae: with me or against me? Infect. Genet. Evol., 2017, 50: 121-127. * Equal contribution. PMID: 27381333
Ishemgulova, A., Butenko, A., Kortišová, L., Boucinha, C., Grybchuk-Ieremenko, A., Morelli, K.A., Tesařová, M., Kraeva, N., Grybchuk, D., Pánek, T., Flegontov, P., Lukeš, J., Votýpka, J., Galvão Pavan, M., Opperdoes, F.R., Spodareva, V., d'Avila-Levy, C., Kostygov, A., Yurchenko, V. Molecular mechanisms of thermal resistance of the insect trypanosomatid Crithidia thermophila. PLoS One, 2017, 12(3): e0174165. PMID: 28328988
Ishemgulova, A.*, Kraeva, N.*, Hlaváčová, J., Zimmer, S., Butenko, A., Podešvová, L., Leštinová, T., Lukeš, J., Kostygov, A., Votýpka, J., Volf, P., Yurchenko, V. A putative ATP/GTP binding protein affects Leishmania mexicana growth in insect vectors and vertebrate hosts. PLoS Negl. Trop. Dis., 2017, 11(7): e0005782. * Equal contribution. PMID: 28742133
Bianchi, C., Kostygov, A., Kraeva, N., Záhonová, K., Horáková, E., Sobotka, R., Lukeš, J., Yurchenko, V. An enigmatic catalase of Blastocrithidia. Mol. Biohem. Parasitol., 2019, 232: 111199. PMID: 31276694
Kraeva, N., Leštinová, T., Ishemgulova, A., Majerová, K., Butenko, A., Vaselek, S., Bespyatykh, J., Charyyeva, A., Spitzová, T., Kostygov, A.Y., Lukeš, J., Volf, P., Votýpka, J., Yurchenko, V. LmxM.22.0250-encoded dual specificity protein/lipid phosphatase impairs Leishmania mexicana virulence in vitro. Pathogens, 2019, 8: E241. PMID: 31744234
Grybchuk, D., Macedo, D.H., Kleschenko, Y., Kraeva, N., Lukashev, A.N., Bates, P.A., Kulich, P., Leštinová, T., Volf, P., Kostygov, A.Y., Yurchenko, V. The first non-LRV RNA virus in Leishmania. Viruses, 2020, 12: 168. PMID: 32024293
Gerasimov, E.S., Zamyatnina, K.A., Matveeva, N.S., Rudenskaya, Y.A., Kraeva, N., Kolesnikov, A.A., Yurchenko, V. Common structural patterns in the maxicircle divergent region of Trypanosomatidae. Pathogens, 2020, 9: 100. PMID: 32033466
Horáková, E., Faktorová, D., Kraeva, N., Kaur, B., Van Den Abbeele, J., Yurchenko, V., Lukeš, J. Catalase compromises the development of the insect and mammalian stages of Trypanosoma brucei. FEBS J., 2020, 287: 964-977. PMID: 31593329
Sádlová, J., Podešvová, L., Bečvář, T., Bianchi, C., Gerasimov, E.S., Saura, A., Glanzová, K., Leštinová, T., Matveeva, N.S., Chmelová, L., Mlacovská, D., Spitzová, T., Vojtková, B., Volf, P., Yurchenko, V.*, Kraeva, N.* Catalase impairs Leishmania mexicana development and virulence. Virulence, 2021, 12(1): 852-867. * Co-correspondent authors. PMID: 33724149
Gerasimov, E.S., Gasparyan, A.A., Afonin, D.A., Zimmer, S.L., Kraeva, N., Lukeš, J., Yurchenko, V., Kolesnikov, A. Complete minicircle genome of Leptomonas pyrrhocoris reveals a source of its non-canonical mitochondrial RNA editing events. Nucl. Acids Res., 2021, 49(6): 3354-3370. PMID: 33660779
Chmelová, L’., Bianchi, C., Albanaz, A.T.S., Režnarová, J., Wheeler, R., Kostygov, A.Y., Kraeva, N., Yurchenko, V. Comparative analysis of three trypanosomatid catalases of different origin. Antioxidants, 2022, 11: 46. PMID: 35052550
Andreu Saura, Ph.D., postdoctoral researcher
Education: Institute for Parasitology and Biomedicine “López-Neyra” (IPBLN-CSIC), National Spanish Research Council, Granada, Spain. Ph.D. 2018
Publications
Sádlová, J., Podešvová, L., Bečvář, T., Bianchi, C., Gerasimov, E.S., Saura, A., Glanzová, K., Leštinová, T., Matveeva, N.S., Chmelová, L., Mlacovská, D., Spitzová, T., Vojtková, B., Volf, P., Yurchenko, V., Kraeva, N. Catalase impairs Leishmania mexicana development and virulence. Virulence, 2021, 12(1): 852-867. PMID: 33724149
Rogozin, I.B., Roche-Lima, A., Tyryshkin, K., Carrasquillo-Carrión, K., Lada, A.G., Poliakov, L.Y., Schwartz, E., Saura, A., Yurchenko, V., Cooper, D.N., Panchenko, A.R., Pavlov, Y.I. DNA methylation, deamination and translesion synthesis combine to generate footprint mutations in cancer driver genes in B-cell derived lymphomas and other cancers. Front. Genetics, 2021, 12: 671866. PMID: 34093666
Zakharova, A., Saura, A., Butenko, A., Podešvová, L., Warmusová, S., Kostygov,A.Y., Nenarokova, A., Lukeš, J., Opperdoes, F.R., Yurchenko, V. A new model trypanosomatid Novymonas esmeraldas: genomic perception of its "Candidatus Pandoraea novymonadis" endosymbiont. mBio, 2021, 12(4): e01606-21. PMID: 34399629
Zakharova, A., Albanaz, A.T.S., Opperdoes, F.R., Škodová-Sveráková, I., Zagirova, D., Saura, A., Chmelová, L’., Gerasimov, E.S., Leštinová, T., Bečvář, T., Sádlová, J., Volf, P., Lukeš, J., Horváth, A., Butenko, A., Yurchenko, V. Leishmania guyanensis M4147 as a new LRV1-bearing model parasite: phosphatidate phosphatase 2-like protein controls cell cycle progression and intracellular lipid content. PLoS Negl. Trop. Dis., 2022, 16(6): e0010510. PMID: 35749562
Saura, A.*, Zakharova, A.*, Klocek, D., Gerasimov, E.S., Butenko, A., Macedo, D.H., Servienė, E., Zagirova, D., Meshcheryakova, A., Rogozin, I.B., Serva, S., Kostygov, A.Y., Yurchenko, V. Elimination of LRVs elicits different responses in Leishmania spp. mSphere, 2022, 7(4): e00335-22. * shared contrinution. PMID: 35943162
Rogozin, I.B., Saura, A., Bykova, A., Brover, V., Yurchenko, V. Deletions across the SARS-CoV-2 genome: molecular mechanisms and putative functional consequences of deletions in accessory genes. Microorganisms, 2023, 11: 229. PMID: 36677521
Anzhelika Butenko, Ph.D., postdoctoral researcher (part-time)
Education: Ostravská Univerzita, Ostrava, Czech Republic. Ph.D. 2017
Publications
Kraeva, N., Butenko, A., Hlaváčová, J., Kostygov, A.Y., Myškova, J., Grybchuk, D., Leštinová, T., Votýpka, J., Volf, P., Opperdoes, F., Flegontov, P., Lukeš, J., Yurchenko, V. Leptomonas seymouri: adaptations to the dixenous life cycle analyzed by genome sequencing, transcriptome profiling and co-infection with Leishmania donovani. PLoS Path., 2015, 11(8): e1005127. PMID: 226317207
Flegontov, P.*, Butenko, A.*, Firsov. S., Kraeva, N., Eliáš, M., Field, M., Filatov, D., Flegontova, O., Gerasimov, E., Hlaváčová, J., Ishemgulova, A., Jackson, A., Kelly, S., Kostygov. A.Y., Logacheva, M., Maslov, D., Opperdoes, F., O'Reilly, A., Sádlová, J., Ševčíková, T., Venkatesh, D., Vlček, Č., Volf, P., Votýpka, J., Záhonová, K., Yurchenko, V., Lukeš, J. Genome of Leptomonas pyrrhocoris: a high-quality reference for monoxenous trypanosomatids and new insights into evolution of Leishmania. Sci. Rep., 2016, 6: 23704. * Equal contribution. PMID: 27021793
Opperdoes, F.*, Butenko, A.*, Flegontov, P., Yurchenko, V., Lukeš, J. Comparative metabolism of free-living Bodo saltans and parasitic trypanosomatids. J. Euk. Microbiol., 2016, 63(5): 657-678. * Equal contribution. PMID: 27009761
Kraeva, N., Horáková, E., Kostygov, A.Y., Kořený, L., Butenko, A., Yurchenko, V., Lukeš, J. Catalase in Leishmaniinae: with me or against me? Infect. Genet. Evol., 2017, 50: 121-127. PMID: 27381333
Ishemgulova, A., Butenko, A., Kortišová, L., Boucinha, C., Grybchuk-Ieremenko, A., Morelli, K.A., Tesařová, M., Kraeva, N., Grybchuk, D., Pánek, T., Flegontov, P., Lukeš, J., Votýpka, J., Galvão Pavan, M., Opperdoes, F.R., Spodareva, V., d'Avila-Levy, C., Kostygov, A.Y., Yurchenko, V. Molecular mechanisms of thermal resistance of the insect trypanosomatid Crithidia thermophila. PLoS One, 2017, 12(3): e0174165. PMID: 28328988
Ishemgulova, A., Kraeva, N., Hlaváčová, J., Zimmer, S., Butenko, A., Podešvová, L., Leštinová, T., Lukeš, J., Kostygov, A.Y., Votýpka, J., Volf, P., Yurchenko, V.* A putative ATP/GTP binding protein affects Leishmania mexicana growth in insect vectors and vertebrate hosts. PLoS Negl. Trop. Dis., 2017, 11(7): e0005782. PMID: 28742133
Lukša, J., Ravoitytė, B., Konovalovas, A., Aitmanaitė, L., Butenko, A., Yurchenko, V., Serva, S., Servienė, E. Different metabolic pathways are involved in response of Saccharomyces cerevisiae to L-A and M viruses. Toxins, 2017, 9: e233. PMID: 28757599
Kostygov, A.Y., Butenko, A., Nenarokova, A., Tashyreva, D., Flegontov, P., Lukeš, J., Yurchenko, V. Genome of Ca. Pandoraea novymonadis, an endosymbiotic bacterium of the trypanosomatid Novymonas esmeraldas. Front. Microbiol., 2017, 8: 1940. PMID: 29046673
Grybchuk, D., Akopyants. N.S., Kostygov, A.Y., Konovalovas, A., Lye, L.-F., Dobson, D.E., Zangger, H., Fasel. N., Butenko, A., Frolov. A.O., Votýpka, J., d'Avila-Levy, C.M., Kulich, P., Moravcová, J., Plevka, P., Rogozin, I.B., Serva, S., Lukeš, J., Beverley, S.M., Yurchenko, V. Viral discovery and diversity in trypanosomatid protozoa with a focus on relatives of the human parasite Leishmania. Proc. Natl. Acad. Sci. USA, 2018, 115(3): E506-E515. PMID: 29284754
Ishemgulova, A., Hlaváčová, J., Majerová, K., Butenko, A., Lukeš, J., Votýpka, J., Volf, P., Yurchenko, V. CRISPR/Cas9 in Leishmania mexicana: a case study of LmxBTN1. PLoS One, 2018, 13(2): e0192723. PMID: 29438445
Butenko, A., da Silva Vieira, T., Frolov, A.O., Opperdoes, F.R., Soares, R.P., Kostygov, A.Y., Lukeš, J., Yurchenko, V. Leptomonas pyrrhocoris: genomic insight into parasite's physiology. Curr. Genomics, 2018, 19(2): 150-156. PMID: 29491743
Záhonová, K., Petrželková, R., Valach, M., Yazaki, E., Tikhonenkov, D., Butenko, A., Janouškovec, J., Hrdá, Š., Klimeš, V., Burger, G., Inagaki, Y., Keeling, P., Hampl, V., Flegontov, P., Yurchenko, V., Eliáš, M. Extensive molecular tinkering in the evolution of the membrane attachment mode of the Rheb GTPase. Sci. Rep., 2018, 8: 5239. PMID: 29588502
Lukeš, J., Butenko, A., Hashimi, H., Maslov, D.A., Votýpka, J., Yurchenko, V. Trypanosomatids are much more than just trypanosomes: clues from the expanded family tree. Trends Parasitol., 2018, 34 (6): 466-480. PMID: 29605546
Silva, F., Kostygov, A.Y., Spodareva, V., Butenko, A., Tossou, R., Lukeš, J., Yurchenko, V., Alves, J. The reduced genome of Candidatus Kinetoplastibacterium sorsogonicusi, the endosymbiont of Kentomonas sorsogonicus (Trypanosomatidae): loss of the heme synthesis pathway. Parasitology, 2018, 145(10): 1287-1293. PMID: 29642956
Kostygov, A.Y., Butenko, A., Yurchenko, V. On monoxenous trypanosomatids from lesions of immunocompetent patients with suspected cutaneous leishmaniasis in Iran. Trop. Med. Int. Health, 2019, 24(1): 127-128. PMID: 30307678
Butenko, A., Kostygov, A.Y., Sádlová, J., Kleschenko, Y., Bečvář, T., Podešvová, L., Macedo, D.H., Žihala, D., Lukeš, J., Bates, P.A., Volf, P., Opperdoes, F.R., Yurchenko, V. Comparative genomics of Leishmania (Mundinia). BMC Genomics, 2019, 20(1): 726. PMID: 31601168
Kraeva, N., Leštinová, T., Ishemgulova, A., Majerová, K., Butenko, A., Vaselek, S., Bespyatykh, J., Charyyeva, A., Spitzová, T., Kostygov, A.Y., Lukeš, J., Volf, P., Votýpka, J., Yurchenko, V. LmxM.22.0250-encoded dual specificity protein/lipid phosphatase impairs Leishmania mexicana virulence in vitro. Pathogens, 2019, 8: E241. PMID: 31744234
d’Avila-Levy, C.M., Bearzatto, B., Ambroise, J., Helaers, R., Butenko, A., Yurchenko, V., Morelli, K.A., Santos, H.L.C., Brouillard, P., Grellier, P., Gala, J.-L., Vikkula, M. First draft genome of the trypanosomatid Herpetomonas muscarum ingenoplastis through MinION Oxford Nanopore technology and Illumina sequencing. Trop. Med. Infect. Dis., 2020, 5: 25. PMID: 32069939
Kostygov, A.Y., Frolov, A.O., Malysheva, M.N., Ganyukova, A.I., Chistyakova, L.V., Tashyreva, D., Tesařová, M., Spodareva, V.V., Režnarová, J., Macedo, D., Butenko, A., d’Avila-Levy, C.M., Lukeš, J., Yurchenko, V. Vickermania gen. nov., trypanosomatids that use two joined flagella to resist midgut peristaltic flow within the fly host. BMC Biol., 2020, 18: 187. PMID: 33267865
Durante, I.*, Butenko, A.*, Rašková, V., Charyyeva, A., Svobodová, M., Yurchenko, V., Hashimi, H., Lukeš, J. Large-scale phylogenetic analysis of trypanosomatid adenylate cyclases reveals associations with extracellular lifestyle and host-pathogen interplay. Genome Biol. Evol., 2020, 12(12): 2403-2416. * Equal contribution. PMID: 33104188
Opperdoes, F.R., Butenko, A., Zakharova, A., Gerasimov, E.S., Zimmer, S.L., Lukeš, J., Yurchenko, V. The remarkable metabolism of Vickermania ingenoplastis: genomic predictions. Pathogens, 2021, 10: 68. PMID: 33466586
Butenko, A., Hammond, M., Field, M., Ginger, M., Yurchenko, V., Lukeš, J. Reductionist pathways for parasitism in euglenozoans? Expanded datasets provide new insights. Trends Parasitol., 2021, 37(2): 100-116. (Review). PMID: 33127331
Albanaz, A.T.S., Gerasimov, E.S., Shaw, J.J., Sádlová, J., Lukeš, J., Volf, P., Opperdoes, F.R., Kostygov, A.Y., Butenko, A.*, Yurchenko, V.* Genome analysis of Endotrypanum and Porcisia spp., closest phylogenetic relatives of Leishmania, highlights the role of amastins in shaping pathogenicity. Genes. 2021, 12(3): 444. * Co-correspondent authors. PMID: 33804709
Poláková, E., Záhonová, K., Albanaz, A.T.S., Butenko, A., Lukeš, J., Yurchenko, V. Diverse telomeres in trypanosomatids. Parasitology, 2021, 148: 1254-1270. PMID: 33612129
Skalický, T., Alves, J.M.P., Morais, A.C., Režnarová, J., Butenko, A., Lukeš, J., Serrano, M.G., Buck, G.A., Teixeira, M.M.G., Camargo, E.P., Sanders, M., Cotton, J.A., Yurchenko, V., Kostygov,A.Y. Endosymbiont capture, a repeated process of endosymbiont transfer with replacement in trypanosomatids Angomonas spp. Pathogens, 2021, 10: 702. PMID: 34200026
Zakharova, A., Saura, A., Butenko, A., Podešvová, L., Warmusová, S., Kostygov, A.Y., Nenarokova, A., Lukeš, J., Opperdoes, F.R., Yurchenko, V. A new model trypanosomatid Novymonas esmeraldas: genomic perception of its "Candidatus Pandoraea novymonadis" endosymbiont. mBio, 2021, 12(4): e01606-21. PMID: 34399629
Yurchenko, V., Butenko, A., Kostygov, A.Y. Genomics of Trypanosomatidae: where we stand and what needs to be done? Pathogens, 2021, 10: 1124. PMID: 34578156
Zakharova, A., Albanaz, A.T.S., Opperdoes, F.R., Škodová-Sveráková, I., Zagirova, D., Saura, A., Chmelová, L’., Gerasimov, E.S., Leštinová, T., Bečvář, T., Sádlová, J., Volf, P., Lukeš, J., Horváth, A., Butenko, A., Yurchenko, V. Leishmania guyanensis M4147 as a new LRV1-bearing model parasite: phosphatidate phosphatase 2-like protein controls cell cycle progression and intracellular lipid content. PLoS Negl. Trop. Dis., 2022, 16(6): e0010510. PMID: 35749562
Saura, A., Zakharova, A., Klocek, D., Gerasimov, E.S., Butenko, A., Macedo, D.H., Servienė, E., Zagirova, D., Meshcheryakova, A., Rogozin, I.B., Serva, S., Kostygov, A.Y., Yurchenko, V. Elimination of LRVs elicits different responses in Leishmania spp. mSphere, 2022, 7(4): e00335-22. PMID: 35943162
Kristína Pašuthová (Záhonová), Ph.D., postdoctoral researcher (part-time)
Education: Ostravská Univerzita, Ostrava, Czech Republic. Ph.D. 2016
Publications
Záhonová, K., Hadariová, L., Vacula, R., Yurchenko, V., Eliáš, M., Krajčovič, J., Vesteg, M. A small portion of plastid transcripts is polyadenylated in the flagellate Euglena gracilis. FEBS Lett., 2014, 588: 783-788. PMID: 24492004
Flegontov, P., Butenko, A., Firsov. S., Kraeva, N., Eliáš, M., Field, M., Filatov, D., Flegontova, O., Gerasimov, E., Hlaváčová, J., Ishemgulova, A., Jackson, A., Kelly, S., Kostygov. A.Y., Logacheva, M., Maslov, D., Opperdoes, F., O'Reilly, A., Sádlová, J., Ševčíková, T., Venkatesh, D., Vlček, Č., Volf, P., Votýpka, J., Záhonová, K., Yurchenko, V., Lukeš, J. Genome of Leptomonas pyrrhocoris: a high-quality reference for monoxenous trypanosomatids and new insights into evolution of Leishmania. Sci. Rep., 2016, 6: 23704. PMID: 27021793
Záhonová, K., Füssy, Z., Oborník, M., Eliáš, M., Yurchenko, V. RuBisCO in non-photosynthetic alga Euglena longa: divergent features, transcriptomic analysis and regulation of complex formation. PLoS One, 2016, 11(7): e0158790. PMID: 27391690
Záhonová, K.*, Kostygov, A.Y.*, Ševčíková, T., Yurchenko, V., Eliáš, M. An unprecedented non-canonical nuclear genetic code with all three termination codons reassigned as sense codons. Curr. Biol., 2016, 26: 2364-2369. * Equal contribution. PMID: 27593378
Záhonová, K., Petrželková, R., Valach, M., Yazaki, E., Tikhonenkov, D., Butenko, A., Janouškovec, J., Hrdá, Š., Klimeš, V., Burger, G., Inagaki, Y., Keeling, P., Hampl, V., Flegontov, P., Yurchenko, V., Eliáš, M. Extensive molecular tinkering in the evolution of the membrane attachment mode of the Rheb GTPase. Sci. Rep., 2018, 8: 5239. PMID: 29588502
Nenarokova, A., Záhonová, K., Krasilnikova, M., Gahura, O., McCulloch, R., Zíková, A., Yurchenko, V., Lukeš, J. Causes and effects of loss of classical non-homologous end joining pathway in parasitic eukaryotes. mBio, 2019, 10(4): e01541-19. PMID: 31311886
Bianchi, C., Kostygov, A.Y., Kraeva, N., Záhonová, K., Horáková, E., Sobotka, R., Lukeš, J., Yurchenko, V. An enigmatic catalase of Blastocrithidia. Mol. Biohem. Parasitol., 2019, 232: 111199. PMID: 31276694
Škodová-Sveráková, I.*, Záhonová, K.*, Bučková, B., Füssy, Z., Yurchenko, V., Lukeš, J. Catalase and ascorbate peroxidase in euglenozoan protists. Pathogens, 2020, 9: 317.* Equal contribution. PMID: 32344595
Füssy, Z.*, Záhonová, K.*, Tomčala, A., Krajčovič, J., Yurchenko, V., Oborník, M., Eliáš, M. The cryptic plastid of Euglena longa defines a new type of nonphotosynthetic plastid organelles. mSphere, 2020, 5(5): e00675-20. * Equal contribution. PMID: 33087518
Poláková, E., Záhonová, K., Albanaz, A.T.S., Butenko, A., Lukeš, J., Yurchenko, V. Diverse telomeres in trypanosomatids. Parasitology, 2021, 148: 1254-1270. PMID: 33612129
Kachale, A., Pavlíková, Z., Nenarokova, A., Roithová, A., Durante, I.M., Miletínová, P., Záhonová, K., Nenarokov, S., Votýpka, J., Horáková, E., Ross, R.L., Yurchenko, V., Beznosková, P., Paris, Z., Valášek, L.S., Lukeš, J. Short tRNA anticodon stem and mutant eRF1 allow stop codon reassignment. Nature, 2023, 613(7945): 751-758. PMID: 36631608
Danil Grybchuk, Ph.D., postdoctoral researcher (part-time)
Education: Ostravská Univerzita, Ostrava, Czech Republic. Ph.D. 2017
Publications
Votýpka, J., Kostygov, A.Y., Kraeva, N., Grybchuk-Ieremenko, A., Tesařová, M., Grybchuk, D., Lukeš, J., Yurchenko, V. Kentomonas gen. n., a new genus of endosymbiont-containing trypanosomatids of Strigomonadinae subfam. n. Protist, 2014, 165: 825-838. PMID: 25460233
Kraeva, N., Butenko, A., Hlaváčová, J., Kostygov, A.Y., Myškova, J., Grybchuk, D., Leštinová, T., Votýpka, J., Volf, P., Opperdoes, F., Flegontov, P., Lukeš, J., Yurchenko, V. Leptomonas seymouri: adaptations to the dixenous life cycle analyzed by genome sequencing, transcriptome profiling and co-infection with Leishmania donovani. PLoS Path., 2015, 11(8): e1005127. PMID: 226317207
Ishemgulova, A., Butenko, A., Kortišová, L., Boucinha, C., Grybchuk-Ieremenko, A., Morelli, K.A., Tesařová, M., Kraeva, N., Grybchuk, D., Pánek, T., Flegontov, P., Lukeš, J., Votýpka, J., Galvão Pavan, M., Opperdoes, F.R., Spodareva, V., d'Avila-Levy, C., Kostygov, A.Y., Yurchenko, V. Molecular mechanisms of thermal resistance of the insect trypanosomatid Crithidia thermophila. PLoS One, 2017, 12(3): e0174165. PMID: 28328988
Grybchuk, D., Akopyants. N.S., Kostygov, A.Y., Konovalovas, A., Lye, L.-F., Dobson, D.E., Zangger, H., Fasel. N., Butenko, A., Frolov. A.O., Votýpka, J., d'Avila-Levy, C.M., Kulich, P., Moravcová, J., Plevka, P., Rogozin, I.B., Serva, S., Lukeš, J., Beverley, S.M., Yurchenko, V. Viral discovery and diversity in trypanosomatid protozoa with a focus on relatives of the human parasite Leishmania. Proc. Natl. Acad. Sci. USA, 2018, 115(3): E506-E515. PMID: 29284754
Grybchuk, D., Kostygov, A.Y., Macedo, D.H., d'Avila-Levy, C.M., Yurchenko, V. RNA viruses in trypanosomatid parasites: a historical overview (Review). Mem. Inst. Oswaldo Cruz, 2018, 113(4): e170487. PMID: 29513877
Grybchuk, D., Kostygov, A.Y., Macedo, D.H., Votýpka, J., Lukeš, J., Yurchenko, V. RNA viruses in Blechomonas (Trypanosomatidae) and evolution of Leishmaniavirus. mBio, 2018, 9(5): e01932-18. PMID: 30327446
Kleschenko, Y.*, Grybchuk, D.*, Matveeva, N.S., Macedo, D.H., Ponirovsky, E.N., Lukashev, A.N., Yurchenko, V. Molecular characterization of LRV2 in Leishmania major from Uzbekistan. Genes, 2019, 10: E830. * Equal contribution. PMID: 31640177
Grybchuk, D.*, Macedo, D.H.*, Kleschenko, Y., Kraeva, N., Lukashev, A.N., Bates, P.A., Kulich, P., Leštinová, T., Volf, P., Kostygov, A.Y., Yurchenko, V. The first non-LRV RNA virus in Leishmania. Viruses, 2020, 12: 168. * Equal contribution. PMID: 32024293
Procházková, M., Füzik, T., Grybchuk, D., Falginella, F., Podešvová, L., Yurchenko, V., Vácha, R., Plevka, P. Capsid structure of Leishmania RNA virus 1. J. Virol., 2021, 95(3): e01957-20. PMID: 33208443
Kostygov, A.Y.*; Grybchuk, D.*, Kleschenko, Y., Chistyakov, D.S., Lukashev, A.N., Gerasimov, E.S., Yurchenko, V. Analyses of Leishmania-LRV co-phylogenetic patterns and evolutionary variability of viral proteins. Viruses, 2021, 13(11): 2305. * Equal contribution. PMID: 34835111
Grybchuk, D., Procházková, M., Füzik, T., Konovalovas, A., Serva, S., Yurchenko, V., Plevka, P. Structures of L-BC virus and its open particle provide insight into Totivirus capsid assembly. Commun. Biol., 2022, 5(1): 847. PMID: 35986212
Procházková, M., Füzik, T., Grybchuk, D., Yurchenko, V., Plevka, P. Virion structure of Leishmania RNA virus 1. Virology, 2022, 577: 149-154. PMID: 36371873
Ingrid Škodová-Sveráková, Ph.D., postdoctoral researcher (part-time)
Education: Univerzita Komenského v Bratislave, Bratislava, Slovakia. Ph.D. 2014
Publications
Škodová-Sveráková, I.*, Záhonová, K.*, Bučková, B., Füssy, Z., Yurchenko, V., Lukeš, J. Catalase and ascorbate peroxidase in euglenozoan protists. Pathogens, 2020, 9: 317. * Equal contribution. PMID: 32344595
Zakharova, A., Albanaz, A.T.S., Opperdoes, F.R., Škodová-Sveráková, I., Zagirova, D., Saura, A., Chmelová, L’., Gerasimov, E.S., Leštinová, T., Bečvář, T., Sádlová, J., Volf, P., Lukeš, J., Horváth, A., Butenko, A., Yurchenko, V. Leishmania guyanensis M4147 as a new LRV1-bearing model parasite: phosphatidate phosphatase 2-like protein controls cell cycle progression and intracellular lipid content. PLoS Negl. Trop. Dis., 2022, 16(6): e0010510. PMID: 35749562
PhD students
Mgr. Viktoria Spodareva, PhD student
Education: Kalmyk State University, Elista, Russia. MSc. 2001
Publications
Ishemgulova, A., Butenko, A., Kortišová, L., Boucinha, C., Grybchuk-Ieremenko, A., Morelli, K.A., Tesařová, M., Kraeva, N., Grybchuk, D., Pánek, T., Flegontov, P., Lukeš, J., Votýpka, J., Galvão Pavan, M., Opperdoes, F.R., Spodareva, V., d'Avila-Levy, C., Kostygov, A., Yurchenko, V. Molecular mechanisms of thermal resistance of the insect trypanosomatid Crithidia thermophila. PLoS One, 2017, 12(3): e0174165. PMID: 28328988
Silva, F., Kostygov, A., Spodareva, V., Butenko, A., Tossou, R., Lukeš, J., Yurchenko, V., Alves, J. The reduced genome of Candidatus Kinetoplastibacterium sorsogonicusi, the endosymbiont of Kentomonas sorsogonicus (Trypanosomatidae): loss of the heme synthesis pathway. Parasitology, 2018, 145(10): 1287-1293. PMID: 29642956
Spodareva, V., Grybchuk-Ieremenko, A., Losev, A., Votýpka, J., Lukeš, J., Yurchenko, V., Kostygov, A. Diversity and evolution of anuran trypanosomes: insights from the study of European species. Parasit. Vectors, 2018, 11: 447. PMID: 30071897
Frolov, A.O, Malysheva, M.N., Ganyukova, A.I., Spodareva, V., Yurchenko, V., Kostygov, A.Y. Development of Phytomonas lipae sp. n. (Kinetoplastea: Trypanosomatidae) in the true bug Coreus marginatus (Heteroptera: Coreidae) and insights into the evolution of life cycles in the genus Phytomonas. PLoS One, 2019, 14(4): e0214484. PMID: 30943229
Frolov, A.O., Malysheva, M.N., Ganyukova, A.I., Spodareva, V.V., Králová, J., Yurchenko, V., Kostygov, A.Y. If host is refractory, insistent parasite goes berserk: trypanosomatid Blastocrithidia raabei in the true bug Coreus marginatus. PLoS One, 2020, 15(1): e0227832. PMID: 31945116
Ganyukova, A.I., Frolov, A.O., Malysheva, M.N., Spodareva, V.V., Yurchenko, V., Kostygov, A.Y. A novel endosymbiont-containing trypanosomatid Phytomonas borealis sp. n. from the predatory bug Picromerus bidens (Heteroptera, Pentatomidae). Folia Parasitol., 2020, 67: 004. PMID: 32350156
Kostygov, A.Y., Frolov, A.O., Malysheva, M.N., Ganyukova, A.I., Chistyakova, L.V., Tashyreva, D., Tesařová, M., Spodareva, V.V., Režnarová, J., Macedo, D., Butenko, A., d’Avila-Levy, C.M., Lukeš, J., Yurchenko, V. Vickermania gen. nov., trypanosomatids that use two joined flagella to resist midgut peristaltic flow within the fly host. BMC Biol., 2020, 18: 187. PMID: 33267865
Mgr. Ester Poláková, PhD student
Education: Ostravská Univerzita, Ostrava, Czech Republic. Mgr. 2018
Publications
Poláková, E., Záhonová, K., Albanaz, A.T.S., Butenko, A., Lukeš, J., Yurchenko, V. Diverse telomeres in trypanosomatids. Parasitology, 2021, 148: 1254-1270. PMID: 33612129
Poláková, E., Albanaz, A.T.S., Zakharova, A., Novozhilova, T.S., Gerasimov, E.S., Yurchenko, V. Ku80 is involved in telomere maintenance but dispensable for genomic stability in Leishmania mexicana. PLoS Negl. Trop. Dis., 2021, 15(12): e0010041. PMID: 34965251
Ennes-Vidal, V., Antunes, D., Poláková, E., Yurchenko, V., Oliveira, S.S.C., Faria da Mota, F., Guimaraes, A.C.R., Caffarena, E.R., Santos , A.L.S, Branquinha, M.H., d’Avila-Levy, C.M. Differences in charge distribution in Leishmania tarentolae leishmanolysin result in a reduced enzymatic activity. Int. J. Mol. Sci., 2022, 23: 7660. PMID:
Mgr. Amanda Albanaz, PhD student
Education: Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. MSc. 2019
Publications
Poláková, E., Záhonová, K., Albanaz, A.T.S., Butenko, A., Lukeš, J., Yurchenko, V. Diverse telomeres in trypanosomatids. Parasitology, 2021, 148: 1254-1270. PMID: 33612129
Albanaz, A.T.S.; Gerasimov, E.S.; Shaw, J.J.; Sádlová, J.; Lukeš, J.; Volf, P.; Opperdoes, F.R.; Kostygov, A.Y.; Butenko, A.; Yurchenko, V. Genome analysis of Endotrypanum and Porcisia spp., closest phylogenetic relatives of Leishmania, highlights the role of amastins in shaping pathogenicity. Genes. 2021, 12(3): 444. PMID: 33804709
Poláková, E., Albanaz, A.T.S., Zakharova, A., Novozhilova, T.S., Gerasimov, E.S., Yurchenko, V. Ku80 is involved in telomere maintenance but dispensable for genomic stability in Leishmania mexicana. PLoS Negl. Trop. Dis., 2021, 15(12): e0010041. PMID: 34965251
Chmelová, L’., Bianchi, C., Albanaz, A.T.S., Režnarová, J., Wheeler, R., Kostygov, A.Y., Kraeva, N., Yurchenko, V. Comparative analysis of three trypanosomatid catalases of different origin. Antioxidants, 2022, 11: 46. PMID: 35052550
Zakharova, A.*, Albanaz, A.T.S.*, Opperdoes, F.R., Škodová-Sveráková, I., Zagirova, D., Saura, A., Chmelová, L’., Gerasimov, E.S., Leštinová, T., Bečvář, T., Sádlová, J., Volf, P., Lukeš, J., Horváth, A., Butenko, A., Yurchenko, V. Leishmania guyanensis M4147 as a new LRV1-bearing model parasite: phosphatidate phosphatase 2-like protein controls cell cycle progression and intracellular lipid content. PLoS Negl. Trop. Dis., 2022, 16(6): e0010510. * shared contribution. PMID: 35749562
Mgr. Anastassia Bykova, PhD student
Education: Moscow State University, Moscow, Russia. MSc. 2020
Publications
Belinky, F., Bykova, A. , Yurchenko, V., Rogozin, I. B. No evidence for widespread positive selection on double substitutions within codons in primates and yeasts. Front. Genetics, 2022, 13: 991249. PMID: 36159983
Rogozin, I.B., Saura, A., Bykova, A., Brover, V., Yurchenko, V. Deletions across the SARS-CoV-2 genome: molecular mechanisms and putative functional consequences of deletions in accessory genes. Microorganisms, 2023, 11: 229. PMID: 36677521
Mgr. Ľubomíra Chmelová, PhD student
Education: Univerzita Komenského v Bratislave, Bratislava, Slovakia. Mgr. 2020
Publications
Sádlová, J., Podešvová, L., Bečvář, T., Bianchi, C., Gerasimov, E.S., Saura, A., Glanzová, K., Leštinová, T., Matveeva, N.S., Chmelová, L., Mlacovská, D., Spitzová, T., Vojtková, B., Volf, P., Yurchenko, V., Kraeva, N. Catalase impairs Leishmania mexicana development and virulence. Virulence, 2021, 12(1): 852-867. PMID: 33724149
Chmelová, L’.*, Bianchi, C.*, Albanaz, A.T.S., Režnarová, J., Wheeler, R., Kostygov, A.Y., Kraeva, N., Yurchenko, V. Comparative analysis of three trypanosomatid catalases of different origin. Antioxidants, 2022, 11: 46. * shared contribution. PMID: 35052550
Zakharova, A., Albanaz, A.T.S., Opperdoes, F.R., Škodová-Sveráková, I., Zagirova, D., Saura, A., Chmelová, L’., Gerasimov, E.S., Leštinová, T., Bečvář, T., Sádlová, J., Volf, P., Lukeš, J., Horváth, A., Butenko, A., Yurchenko, V. Leishmania guyanensis M4147 as a new LRV1-bearing model parasite: phosphatidate phosphatase 2-like protein controls cell cycle progression and intracellular lipid content. PLoS Negl. Trop. Dis., 2022, 16(6): e0010510. PMID: 35749562
Magri, A., Bianchi, C., Chmelová, L′., Caffara, M., Galuppi, R., Fioravanti, M., Yurchenko, V., Kostygov, A.Y. Roe deer (Capreolus capreolus) are a novel potential reservoir for human visceral leishmaniasis in the Emilia-Romagna region of Northeastern Italy. Int. J. Parasitol., 2022, 52(12): 745-750. PMID: 36265672
Mgr. Arnau Galan Rigol, PhD student
Education: Universitat de Barcelona, Barcelona, Spain. MSc. 2021
Master students
Adam Krayzel (supervised by Dr. Natalya Kraeva)
Volunteers
Donna Klocek
Publications
Saura, A., Zakharova, A., Klocek, D., Gerasimov, E.S., Butenko, A., Macedo, D.H., Servienė, E., Zagirova, D., Meshcheryakova, A., Rogozin, I.B., Serva, S., Kostygov, A.Y., Yurchenko, V. Elimination of LRVs elicits different responses in Leishmania spp. mSphere, 2022, 7(4): e00335-22. PMID: 35943162
Lab alumni, postdocs
Dr. Aleksander Losev
2015
Dr. Claretta Bianchi
2022
Lab alumni, Ph.D. students
Dr. Natalya Kraeva
2017, Ph.D. thesis: "Analysis of genetic differences between monoxenous and dixenous Leishmaniinae for identification of novel virulence factors"
Dr. Anastasiia Grybchuk-Ieremenko
2017, Ph.D. thesis: "Diversity and molecular phylogeny of monoxenous insect trypanosomatids and trypanosomes from freshwater vertebrates"
Dr. Aygul Ishemgulova
2017, Ph.D. thesis: "Functional genomics of Leishmania virulence"
Dr. Danyil Grybchuk
2017, Ph.D. thesis: "Diversity and phylogeny of RNA viruses in Trypanosomatidae with insights into viral ecology and host cell interaction"
Dr. Lucie Podešvová
2020, Ph.D. thesis: "The new molecular tools for Leishmania research"
Dr. Diego Henrique Fagundes Macedo
2021, Ph.D. thesis: "Jumping on the viral bandwagon: a study on the diversity and evolution of RNA viruses in trypanosomatids with the emphasis on leishmaniaviruses"
Dr. Jana Režnarová (Králová) (supervised by Dr. Alexei Kostygov)
2021, Ph.D. thesis: "Diversity and biology of monoxenous trypanosomatids on a broad and specific scale"
Dr. Arzuv Charyyeva
2021, Ph.D. thesis: "Leishmania virulence: from haplotype network to functional genomics"
Dr. Claretta Bianchi
2022, Ph.D. thesis: "Catalase: what happened in the evolution of Trypanosomatidae?"
Dr. Alexandra Zakharova
2023, Ph.D. thesis: "The inner society of endosymbionts in Leishmaniinae"
Lab alumni, MSc. students
Mgr. Lucie Kortišová, 2015
Mgr. Dalibor Váhala, 2015
Mgr. Denisa Mlacovská, 2017
Mgr. Adriana Volná, 2017
Mgr. Martin Kovačik, 2018
Mgr. Alena Dembitskaya, 2019
Mgr. Sabina Kühnelová, 2019 (supervised by Dr. Alexei Kostygov)
Mgr. Sandra Warmusová, 2022