Vyacheslav Yurchenko

Personnel

Alexei Kostygov, Ph.D., postdoctoral researcher

Education: Zoological Institute, Russian Academy of Sciences, St. Petersburg, Russia. Ph.D. 2013

Alexei Kostygov

Publications

  • Kostygov, A.Y., Grybchuk-Ieremenko, A., Malysheva, M., Frolov, A., Yurchenko, V. Molecular revision of the genus Wallaceina. Protist, 2014, 165: 594-604. PMID: 25113831
  • Chistyakova, L., Kostygov, A.Y., Kornilova, O., Yurchenko, V. Reisolation and redescription of Balantidium duodeni Stein, 1867 (Litostomatea, Trichostomatia). Parasitol. Res., 2014, 113: 4207–4215. PMID: 25185665
  • Votýpka, J.*, Kostygov, A.Y.*, Kraeva, N., Grybchuk-Ieremenko, A., Tesařová, M., Grybchuk, D., Lukeš, J., Yurchenko, V. Kentomonas gen. n., a new genus of endosymbiont-containing trypanosomatids of Strigomonadinae subfam. n. Protist, 2014, 165: 825-838. * Equal contribution. PMID: 25460233
  • Grybchuk-Ieremenko, A., Losev, A., Kostygov, A.Y., Lukeš, J., Yurchenko, V. High prevalence of trypanosome co-infections in freshwater fishes. Folia Parasitol., 2014, 61: 495-504. PMID: 25651690
  • Losev, A., Grybchuk-Ieremenko, A., Kostygov, A.Y., Lukeš, J., Yurchenko, V. Host specificity, pathogenicity and mixed infections of trypanoplasms from freshwater fishes. Parasitol. Res., 2015, 114:1071–1078. PMID: 25544706
  • Kraeva, N., Butenko, A., Hlaváčová, J., Kostygov, A.Y., Myškova, J., Grybchuk, D., Leštinová, T., Votýpka, J., Volf, P., Opperdoes, F., Flegontov, P., Lukeš, J., Yurchenko, V. Leptomonas seymouri: adaptations to the dixenous life cycle analyzed by genome sequencing, transcriptome profiling and co-infection with Leishmania donovani. PLoS Path., 2015, 11(8): e1005127. PMID: 226317207
  • d'Avila-Levy, C., Boucinha, C., Kostygov, A.Y., Santos, H. L. C., Morelli, K. A., Grybchuk-Ieremenko, A., Duval, L., Votýpka, J., Yurchenko, V., Grellier, P., Lukeš, J. Exploring environmental diversity of kinetoplastid flagellates in the high-throughput DNA sequencing era (Review). Mem Inst Oswaldo Cruz, 2015, 110(8): 956-965. PMID: 26602872
  • Frolov, A., Malysheva, M., Yurchenko, V., Kostygov, A.Y.* Back to monoxeny: Phytomonas nordicus descended from dixenous plant parasites. Eur. J. Protistol., 2016, 52 (1):1-10. * Correspondent author. PMID: 26555733
  • Yurchenko, V., Kostygov, A.Y., Havlová, J., Grybchuk-Ieremenko, A., Ševčíková, T., Lukeš, J., Ševčík, J., Votýpka, J. Diversity of trypanosomatids in cockroaches and the description of Herpetomonas tarakana sp. n. J. Euk. Microbiol., 2016, 63: 198-209. PMID: 26352484
  • Kostygov, A.Y.*, Dobáková, E.*, Grybchuk-Ieremenko, A.*, Váhala, D., Maslov, D., Votýpka, J., Lukeš, J., Yurchenko, V. Novel trypanosomatid – bacterium association: evolution of endosymbiosis in action. mBio, 2016, 7(2): e01985-15. * Equal contribution. PMID: 26980834
  • Flegontov, P., Butenko, A., Firsov. S., Kraeva, N., Eliáš, M., Field, M., Filatov, D., Flegontova, O., Gerasimov, E., Hlaváčová, J., Ishemgulova, A., Jackson, A., Kelly, S., Kostygov, A.Y., Logacheva, M., Maslov, D., Opperdoes, F., O'Reilly, A., Sádlová, J., Ševčíková, T., Venkatesh, D., Vlček, Č., Volf, P., Votýpka, J., Záhonová, K., Yurchenko, V., Lukeš, J. Genome of Leptomonas pyrrhocoris: a high-quality reference for monoxenous trypanosomatids and new insights into evolution of Leishmania. Sci. Rep., 2016, 6: 23704. PMID: 27021793
  • Záhonová, K.*, Kostygov, A.Y.*, Ševčíková, T., Yurchenko, V., Eliáš, M. An unprecedented non-canonical nuclear genetic code with all three termination codons reassigned as sense codons. Curr. Biol., 2016, 26: 2364-2369. * Equal contribution. PMID: 27593378
  • Kraeva, N., Horáková, E., Kostygov, A.Y., Kořený, L., Butenko, A., Yurchenko, V., Lukeš, J. Catalase in Leishmaniinae: with me or against me? Infect. Genet. Evol., 2017, 50: 121-127. PMID: 27381333
  • Frolov, A., Malysheva, M., Ganyukova, A., Yurchenko, V., Kostygov, A.Y.* Life cycle of Blastocrithidia papi sp. n. (Kinetoplastea, Trypanosomatidae) in Pyrrhocoris apterus (Hemiptera, Pyrrhocoridae). Eur. J. Protistol., 2017, 57: 85-98. * Correspondent author. PMID: 28073072
  • Ishemgulova, A., Butenko, A., Kortišová, L., Boucinha, C., Grybchuk-Ieremenko, A., Morelli, K.A., Tesařová, M., Kraeva, N., Grybchuk, D., Pánek, T., Flegontov, P., Lukeš, J., Votýpka, J., Galvão Pavan, M., Opperdoes, F.R., Spodareva, V., d'Avila-Levy, C., Kostygov, A.Y.*, Yurchenko, V.* Molecular mechanisms of thermal resistance of the insect trypanosomatid Crithidia thermophila. PLoS One, 2017, 12(3): e0174165. * Co-correspondent authors. PMID: 28328988
  • Kostygov, A.Y., Yurchenko, V. Revised classification of the subfamily Leishmaniinae (Trypanosomatidae). Folia Parasitol., 2017, 64: 020. PMID: 28783029
  • Ishemgulova, A., Kraeva, N., Hlaváčová, J., Zimmer, S., Butenko, A., Podešvová, L., Leštinová, T., Lukeš, J., Kostygov, A.Y., Votýpka, J., Volf, P., Yurchenko, V. A putative ATP/GTP binding protein affects Leishmania mexicana growth in insect vectors and vertebrate hosts. PLoS Negl. Trop. Dis., 2017, 11(7): e0005782. PMID: 28742133
  • Kostygov, A.Y.*, Butenko, A.*, Nenarokova, A., Tashyreva, D., Flegontov, P., Lukeš, J., Yurchenko, V. Genome of Ca. Pandoraea novymonadis, an endosymbiotic bacterium of the trypanosomatid Novymonas esmeraldas. Front. Microbiol., 2017, 8: 1940. * Equal contribution. PMID: 29046673.
  • Butenko, A., da Silva Vieira, T., Frolov, A.O., Opperdoes, F.R., Soares, R.P., Kostygov, A.Y., Lukeš, J., Yurchenko, V. Leptomonas pyrrhocoris: genomic insight into parasite's physiology. Curr. Genomics, 2018, 19(2): 150-156. PMID: 29491743
  • Grybchuk, D., Akopyants. N.S., Kostygov, A.Y., Konovalovas, A., Lye, L.-F., Dobson, D.E., Zangger, H., Fasel. N., Butenko, A., Frolov. A.O., Votýpka, J., d'Avila-Levy, C.M., Kulich, P., Moravcová, J., Plevka, P., Rogozin, I.B., Serva, S., Lukeš, J., Beverley, S.M., Yurchenko, V. Viral discovery and diversity in trypanosomatid protozoa with a focus on relatives of the human parasite Leishmania. Proc. Natl. Acad. Sci. USA, 2018, 115(3): E506-E515. PMID: 29284754
  • Grybchuk, D., Kostygov, A.Y., Macedo, D.H., d'Avila-Levy, C.M., Yurchenko, V. RNA viruses in trypanosomatid parasites: a historical overview (Review). Mem. Inst. Oswaldo Cruz, 2018, 113(4): e170487. PMID: 29513877
  • Silva, F., Kostygov, A.Y., Spodareva, V., Butenko, A., Tossou, R., Lukeš, J., Yurchenko, V., Alves, J. The reduced genome of Candidatus Kinetoplastibacterium sorsogonicusi, the endosymbiont of Kentomonas sorsogonicus (Trypanosomatidae): loss of the heme synthesis pathway. Parasitology, 2018, 145(10): 1287-1293. PMID: 29642956
  • Spodareva, V., Grybchuk-Ieremenko, A., Losev, A., Votýpka, J., Lukeš, J., Yurchenko, V.*, Kostygov, A.Y.* Diversity and evolution of anuran trypanosomes: insights from the study of European species. Parasit. Vectors, 2018, 11: 447. * Co-correspondent authors. PMID: 30071897
  • Frolov, A., Malysheva, M., Ganyukova, A., Yurchenko, V., Kostygov, A.Y.* Obligate development of Blastocrithidia papi (Trypanosomatidae) in the Malpighian tubules of Pyrrhocoris apterus (Hemiptera) and coordination of host-parasite life cycles. PLoS One, 2018, 13(9): e0204467. * Correspondent author. PMID: 30261003
  • Grybchuk, D., Kostygov, A.Y., Macedo, D.H., Votýpka, J., Lukeš, J., Yurchenko, V. RNA viruses in Blechomonas (Trypanosomatidae) and evolution of Leishmaniavirus. mBio, 2018, 9(5): e01932-18. PMID: 30327446
  • Maslov, D.A., Opperdoes, F.R., Kostygov, A.Y., Hashimi, H., Lukeš, J., Yurchenko, V. Recent advances in trypanosomatid research: genome organization, expression, metabolism, taxonomy, and evolution (Review). Parasitology, 2019, 146(1): 1-27. PMID: 29898792
  • Kostygov, A.Y., Butenko, A., Yurchenko, V. On monoxenous trypanosomatids from lesions of immunocompetent patients with suspected cutaneous leishmaniasis in Iran. Trop. Med. Int. Health, 2019, 24(1): 127-128. PMID: 30307678
  • Frolov, A.O, Malysheva, M.N., Ganyukova, A.I., Spodareva, V.V., Yurchenko, V., Kostygov, A.Y.* Development of Phytomonas lipae sp. n. (Kinetoplastea: Trypanosomatidae) in the true bug Coreus marginatus (Heteroptera: Coreidae) and insights into the evolution of life cycles in the genus Phytomonas. PLoS One, 2019, 14(4): e0214484. * Correspondent author. PMID: 30943229
  • Bianchi, C., Kostygov, A.Y., Kraeva, N., Záhonová, K., Horáková, E., Sobotka, R., Lukeš, J., Yurchenko, V. An enigmatic catalase of Blastocrithidia. Mol. Biohem. Parasitol., 2019, 232: 111199. PMID: 31276694
  • Butenko, A., Kostygov, A.Y., Sádlová, J., Kleschenko, Y., Bečvář, T., Podešvová, L., Macedo, D.H., Žihala, D., Lukeš, J., Bates, P.A., Volf, P., Opperdoes, F.R., Yurchenko, V. Comparative genomics of Leishmania (Mundinia). BMC Genomics, 2019, 20(1): 726. PMID: 31601168
  • Kraeva, N., Leštinová, T., Ishemgulova, A., Majerová, K., Butenko, A., Vaselek, S., Bespyatykh, J., Charyyeva, A., Spitzová, T., Kostygov, A.Y., Lukeš, J., Volf, P., Votýpka, J., Yurchenko, V. LmxM.22.0250-encoded dual specificity protein/lipid phosphatase impairs Leishmania mexicana virulence in vitro. Pathogens, 2019, 8: E241. PMID: 31744234
  • Králová, J., Grybchuk-Ieremenko, A., Votýpka, J., Novotný, V., Kment, P., Lukeš, J., Yurchenko, V.*, Kostygov, A.Y.* Insect trypanosomatids in Papua New Guinea: high endemism and diversity. Int. J. Parasitol., 2109, 49: 1075-1086. * Co-correspondent authors. PMID: 31734337
  • Frolov, A.O., Malysheva, M.N., Ganyukova, A.I., Spodareva, V.V., Králová, J., Yurchenko, V., Kostygov, A.Y.* If host is refractory, insistent parasite goes berserk: trypanosomatid Blastocrithidia raabei in the true bug Coreus marginatus. PLoS One, 2020, 15(1): e0227832. * Correspondent author. PMID: 31945116
  • Grybchuk, D., Macedo, D.H., Kleschenko, Y., Kraeva, N., Lukashev, A.N., Bates, P.A., Kulich, P., Leštinová, T., Volf, P., Kostygov, A.Y.*, Yurchenko, V.* The first non-LRV RNA virus in Leishmania. Viruses, 2020, 12: 168. * Co-correspondent authors. PMID: 32024293
  • Ganyukova, A.I., Frolov, A.O., Malysheva, M.N., Spodareva, V.V., Yurchenko, V., Kostygov, A.Y.* A novel endosymbiont-containing trypanosomatid Phytomonas borealis sp. n. from the predatory bug Picromerus bidens (Heteroptera, Pentatomidae). Folia Parasitol., 2020, 67: 004. * Correspondent author. PMID: 32350156
  • Kostygov, A.Y.*, Frolov, A.O., Malysheva, M.N., Ganyukova, A.I., Chistyakova, L.V., Tashyreva, D., Tesařová, M., Spodareva, V.V., Režnarová, J., Macedo, D., Butenko, A., d’Avila-Levy, C.M., Lukeš, J., Yurchenko, V. Vickermania gen. nov., trypanosomatids that use two joined flagella to resist midgut peristaltic flow within the fly host. BMC Biol., 2020, 18: 187. * Correspondent author. PMID: 33267865
  • Kostygov, A.Y., Karnkowska, A., Votýpka, J., Tashyreva, D., Maciszewski, K., Yurchenko, V., Lukeš, J. Euglenozoa: taxonomy, diversity and ecology, symbioses and viruses. Open Bio., 2021, 11: 200407. PMID: 33715388
  • Charyyeva, A., Çetinkaya, Ü., Özkan. B., Şahin, S., Yaprak, N., Şahin, I., Yurchenko, V.*, Kostygov, A.Y.* Genetic diversity of Leishmania tropica: unexpectedly complex distribution pattern. Acta Trop., 2021, 218: 105888. * Co-correspondent authors. PMID: 33713626
  • Albanaz, A.T.S.; Gerasimov, E.S.; Shaw, J.J.; Sádlová, J.; Lukeš, J.; Volf, P.; Opperdoes, F.R.; Kostygov, A.Y.; Butenko, A.; Yurchenko, V. Genome analysis of Endotrypanum and Porcisia spp., closest phylogenetic relatives of Leishmania, highlights the role of amastins in shaping pathogenicity. Genes. 2021, 12(3): 444. PMID: 33804709
  • Frolov, A.O.*, Kostygov,A.Y.*, Yurchenko, V.* Development of monoxenous trypanosomatids and phytomonads in insects. Trends Parasitol., 2021, 37(6): 538-551. * Co-correspondent authors. PMID: 33714646
  • Skalický, T., Alves, J.M.P., Morais, A.C., Režnarová, J., Butenko, A., Lukeš, J., Serrano, M.G., Buck, G.A., Teixeira, M.M.G., Camargo, E.P., Sanders, M., Cotton, J.A., Yurchenko, V., Kostygov,A.Y.* Endosymbiont capture, a repeated process of endosymbiont transfer with replacement in trypanosomatids Angomonas spp. Pathogens, 2021, 10: 702. * Correspondent author. PMID: 34200026
  • Kostygov,A.Y.*, Alves, J.M.P.*, Yurchenko, V.* Editorial: symbioses between protists and bacteria/archaea. Front. Microbiol., 2021, 12: 709184. * Co-correspondent authors. PMID: 34394058
  • Zakharova, A., Saura, A., Butenko, A., Podešvová, L., Warmusová, S., Kostygov,A.Y., Nenarokova, A., Lukeš, J., Opperdoes, F.R., Yurchenko, V. A new model trypanosomatid Novymonas esmeraldas: genomic perception of its "Candidatus Pandoraea novymonadis" endosymbiont. mBio, 2021, 12(4): e01606-21. PMID: 34399629
  • Yurchenko, V.*, Butenko, A., Kostygov, A.Y.* Genomics of Trypanosomatidae: where we stand and what needs to be done? Pathogens, 2021, 10: 1124. * Co-correspondent authors. PMID: 34578156
  • Kostygov, A.Y.*; Grybchuk, D., Kleschenko, Y., Chistyakov, D.S., Lukashev, A.N., Gerasimov, E.S., Yurchenko, V.* Analyses of Leishmania-LRV co-phylogenetic patterns and evolutionary variability of viral proteins. Viruses, 2021, 13(11): 2305. * Co-correspondent authors. PMID: 34835111
  • Chmelová, L’., Bianchi, C., Albanaz, A.T.S., Režnarová, J., Wheeler, R., Kostygov, A.Y., Kraeva, N., Yurchenko, V. Comparative analysis of three trypanosomatid catalases of different origin. Antioxidants, 2022, 11: 46. PMID: 35052550
  • Kostygov, A.Y.*, Frolov, A.O., Malysheva, M.N., Ganyukova, A.I., Drachko, D., Yurchenko, V., Agasoy, V.V. Development of two species of the Trypanosoma theileri complex in tabanids. Parasit. Vectors, 2022, 15: 95. * Correspondent author. PMID: 35313955
  • Saura, A., Zakharova, A., Klocek, D., Gerasimov, E.S., Butenko, A., Macedo, D.H., Servienė, E., Zagirova, D., Meshcheryakova, A., Rogozin, I.B., Serva, S., Kostygov, A.Y.*, Yurchenko, V.* Elimination of LRVs elicits different responses in Leishmania spp. mSphere, 2022, 7(4): e00335-22. * Co-correspondent authors. PMID: 35943162
  • Kostygov, A.Y.*, Malysheva, M.N., Ganyukova, A.I., Razygraev, A.V., Drachko, D.O., Yurchenko, V., Agasoi, V.V., Frolov, A.O. The roles of mosquitoes in the circulation of monoxenous trypanosomatids in temperate climates. Pathogens, 2022, 11: 1326. * Correspondent author. PMID: 36422578
  • Magri, A.*, Bianchi, C., Chmelová, L′., Caffara, M., Galuppi, R., Fioravanti, M., Yurchenko, V.*, Kostygov, A.Y.* Roe deer (Capreolus capreolus) are a novel potential reservoir for human visceral leishmaniasis in the Emilia-Romagna region of Northeastern Italy. Int. J. Parasitol., 2022, 52(12): 745-750. * Co-correspondent authors. PMID: 36265672
  • Jászayová, A., Režnarová, J., Chovancová, G., Kostygov, A.Y., Yurchenko, V., Antolová, D., Zwijacz-Kozica, T., Csanády, A., Hurníková, Z. A study of oribatid mites as potential intermediate hosts of anoplocephalid tapeworms of Tatra chamois and Tatra marmots from the Tatra Mountains, Central Europe, and report of a new intermediate host for Andrya cuniculi, the parasite of Leporidae. Life, 2023, 13(4): 955. PMID: 37109484
  • Zakharova, A., Tashyreva, D., Butenko, A., Morales, J., Saura, A., Svobodová, M., Poschmann, G., Nandipati, S., Zakharova, A., Noyvert, D., Gahura, O., Týč, J., Stühler, K., Kostygov, A.Y.*, Nowack, E.C.M., Lukeš, J., Yurchenko, V.* A neo-functionalized homolog of host transmembrane protein controls localization of bacterial endosymbionts in the trypanosomatid Novymonas esmeraldas. Curr. Biol., 2023, 33(13): 2690-2701. * Co-correspondent authors. PMID: 37201521
  • Albanaz, A.T.S., Butenko, A., Kostygov, A.Y., Votýpka, J., Yurchenko, V. Transcriptome of Lafontella sp., an obscure relative of Phytomonas and Herpetomonas. Protistology, 2023, 17(2): 109-117
  • Klocek, D., Grybchuk, D., Tichá, L., Votýpka, J., Volf, P., Kostygov, A.Y.*, Yurchenko, V.* Evolution of RNA viruses in trypanosomatids: new insights from the analysis of Sauroleishmania. Parasitol. Res., 2023, 122(10): 2279-2286. * Co-correspondent authors. PMID: 37490143
  • Albanaz, A.T.S., Carrington, M., Frolov, A.O., Ganyukova, A.I., Gerasimov, E.S., Kostygov, A.Y., Lukeš, J., Malysheva, M.N., Votýpka, J., Zakharova, A., Záhonová, K., Zimmer, S.L., Yurchenko, V., Butenko, A. Shining the spotlight on the neglected: new high-quality genome assemblies as a gateway to understanding the evolution of Trypanosomatidae. BMC Genomics, 2023, 24: 471. PMID: 37605127
  • Macedo, D.H., Grybchuk, D., Režnarová, J., Votýpka, J., Klocek, D., Yurchenko, T., Ševčík, J., Magri, A., Urda Dolinská, M., Záhonová, K., Lukeš, J., Servienė, E., Jászayová, A., Serva, S., Malysheva, M.N., Frolov, A.O., Yurchenko, V.*, Kostygov, A.Y.* Diversity of RNA viruses in the cosmopolitan monoxenous trypanosomatid Leptomonas pyrrhocoris. BMC Biol., 2023, 21(1): 191. * Co-correspondent authors. PMID: 37697369
  • Klocek, D., Grybchuk, D., Macedo, D.H., Galan, A., Votýpka, J., Schmid-Hempel, R., Schmid-Hempel, P., Yurchenko, V.*, Kostygov, A.Y.* RNA viruses of Crithidia bombi, a parasite of bumblebees. J. Invertebr. Pathol., 2023, 201: 107991. * Co-correspondent authors. PMID: 37714407
  • Kostygov, A.Y.*, Chmelová, L′., Reichl, J., Jászayová, A., Votýpka, J., Fuehrer, H.-P., Yurchenko, V.* Parasites of firebugs in Austria with focus on the "micro"-diversity of the cosmopolitan trypanosomatid Leptomonas pyrrhocoris. Parasitol. Res., 2024, 123(1): 27. * Co-correspondent authors. PMID: 38072883
  • Kostygov, A.Y.*#, Albanaz, A.T.S.#, Butenko, A., Gerasimov, E.S., Lukeš, J., Yurchenko, V.* Phylogenetic framework to explore trait evolution in Trypanosomatidae. Trends Parasitol., 2024, 40(2): 96-99. # shared contribution. * Co-correspondent authors. PMID: 38065790
  • Zavataro, A.L.E., Skýpalová, K., Vergara, P.O.T., Silva, F.M, Butenko, A., Yurchenko, V., Kostygov, A.Y., Alves, J.M.P. The genome of the endosymbiont-harboring trypanosomatid Kentomonas sorsogonicus. Protistology, 2024, 18(1): 72-81
  • Chmelová, L′., Kraeva, N., Saura, A., Krayzel, A., Vieira, C.S., Ferreira, T.N., Soares, R.P., Bučková, B., Galan, A., Horáková, E., Vojtková, B., Sádlová, J., Malysheva, M.N., Butenko, A., Prokopchuk, G., Frolov, A.O., Lukeš, J., Horváth, A., Škodová-Sveráková, I., Feder, D., Kostygov, A.Y., Yurchenko, V. Intricate balance of dually-localized catalase modulates infectivity of Leptomonas seymouri (Kinetoplastea: Trypanosomatidae). Int. J. Parasitol., 2024 (in press). PMID: 38663543
  • Grybchuk, D., Galan, A., Klocek, D., Macedo, D.H., Wolf, Y.I., Votýpka, J., Butenko, A., Lukeš, J., Neri, U., Záhonová, K., Kostygov, A.Y., Koonin, E.V., Yurchenko, V. Identification of diverse RNA viruses in Obscuromonas flagellates (Euglenozoa: Trypanosomatidae: Blastocrithidiinae). Virus Evol., 2024 (in press). PMID:
  • Grybchuk, D., Kostygov, A.Y., Yurchenko, V. Analysis of Leishbuviridae from trypanosomatids. In: Bunyaviruses: Methods and Protocols (Ed. H. Boshra), 2024, (in press). (ISBN "Methods in Molecular Biology " Series xxx, ISBN xxx).
  • Natalia Kraeva, Ph.D., postdoctoral researcher

    Education: Ostravská Univerzita, Ostrava, Czech Republic. Ph.D. 2017

    Natalya Kraeva

    Publications

  • Votýpka, J., Suková, E., Kraeva, N., Ishemgulova, A., Duží, I., Lukeš, J., Yurchenko, V. Diversity of trypanosomatids (Kinetoplastea: Trypanosomatidae) parasitizing fleas (Insecta: Siphonaptera) and description of a new genus Blechomonas gen. n. Protist, 2013, 164: 763-781. PMID: 24113136
  • Yurchenko, V., Votýpka, J., Tesařová, M., Klepetková, H., Kraeva, N., Jirků, M., Lukeš, J. Ultrastructure and molecular phylogeny of four new species of monoxenous trypanosomatids from flies (Diptera: Brachycera) with redefinition of the genus Wallaceina. Folia Parasitol., 2014, 61: 97-112. PMID: 24822316
  • Votýpka, J., Kostygov, A., Kraeva, N., Grybchuk-Ieremenko, A., Tesařová, M., Grybchuk, D., Lukeš, J., Yurchenko, V. Kentomonas gen. n., a new genus of endosymbiont-containing trypanosomatids of Strigomonadinae subfam. n. Protist, 2014, 165: 825-838. PMID: 25460233
  • Kraeva, N., Ishemgulova, A., Lukeš, J., Yurchenko, V. Tetracycline-inducible gene expression system in Leishmania mexicana. Mol. Biochem. Parasitol., 2014, 198: 11-13. PMID: 25461484
  • Kraeva, N., Butenko, A., Hlaváčová, J., Kostygov, A., Myškova, J., Grybchuk, D., Leštinová, T., Votýpka, J., Volf, P., Opperdoes, F., Flegontov, P., Lukeš, J., Yurchenko, V. Leptomonas seymouri: adaptations to the dixenous life cycle analyzed by genome sequencing, transcriptome profiling and co-infection with Leishmania donovani. PLoS Path., 2015, 11(8): e1005127. PMID: 226317207
  • Kozminsky, E., Kraeva, N., Ishemgulova, A., Dobáková, E., Lukeš, J., Kment, P., Yurchenko, V., Votýpka, J., Maslov, D. Host-specificity of monoxenous trypanosomatids: statistical analysis of the distribution and transmission patterns of the parasites from Neotropical Heteroptera. Protist, 2015, 166(5): 551-568. PMID: 26466163
  • Flegontov, P., Butenko, A., Firsov. S., Kraeva, N., Eliáš, M., Field, M., Filatov, D., Flegontova, O., Gerasimov, E., Hlaváčová, J., Ishemgulova, A., Jackson, A., Kelly, S., Kostygov. A., Logacheva, M., Maslov, D., Opperdoes, F., O'Reilly, A., Sádlová, J., Ševčíková, T., Venkatesh, D., Vlček, Č., Volf, P., Votýpka, J., Záhonová, K., Yurchenko, V., Lukeš, J. Genome of Leptomonas pyrrhocoris: a high-quality reference for monoxenous trypanosomatids and new insights into evolution of Leishmania. Sci. Rep., 2016, 6: 23704. PMID: 27021793
  • Ishemgulova, A., Kraeva, N., Faktorová, D., Podešvová, L., Lukeš, J., Yurchenko, V. T7 polymerase-driven transcription is downregulated in metacyclic promastigote and amastigote Leishmania mexicana. Folia Parasitol., 2016, 63: 016. PMID: 27311571
  • Kraeva, N.*, Horáková, E.*, Kostygov, A., Kořený, L., Butenko, A., Yurchenko, V., Lukeš, J. Catalase in Leishmaniinae: with me or against me? Infect. Genet. Evol., 2017, 50: 121-127. * Equal contribution. PMID: 27381333
  • Ishemgulova, A., Butenko, A., Kortišová, L., Boucinha, C., Grybchuk-Ieremenko, A., Morelli, K.A., Tesařová, M., Kraeva, N., Grybchuk, D., Pánek, T., Flegontov, P., Lukeš, J., Votýpka, J., Galvão Pavan, M., Opperdoes, F.R., Spodareva, V., d'Avila-Levy, C., Kostygov, A., Yurchenko, V. Molecular mechanisms of thermal resistance of the insect trypanosomatid Crithidia thermophila. PLoS One, 2017, 12(3): e0174165. PMID: 28328988
  • Ishemgulova, A.*, Kraeva, N.*, Hlaváčová, J., Zimmer, S., Butenko, A., Podešvová, L., Leštinová, T., Lukeš, J., Kostygov, A., Votýpka, J., Volf, P., Yurchenko, V. A putative ATP/GTP binding protein affects Leishmania mexicana growth in insect vectors and vertebrate hosts. PLoS Negl. Trop. Dis., 2017, 11(7): e0005782. * Equal contribution. PMID: 28742133
  • Bianchi, C., Kostygov, A., Kraeva, N., Záhonová, K., Horáková, E., Sobotka, R., Lukeš, J., Yurchenko, V. An enigmatic catalase of Blastocrithidia. Mol. Biohem. Parasitol., 2019, 232: 111199. PMID: 31276694
  • Kraeva, N., Leštinová, T., Ishemgulova, A., Majerová, K., Butenko, A., Vaselek, S., Bespyatykh, J., Charyyeva, A., Spitzová, T., Kostygov, A.Y., Lukeš, J., Volf, P., Votýpka, J., Yurchenko, V. LmxM.22.0250-encoded dual specificity protein/lipid phosphatase impairs Leishmania mexicana virulence in vitro. Pathogens, 2019, 8: E241. PMID: 31744234
  • Grybchuk, D., Macedo, D.H., Kleschenko, Y., Kraeva, N., Lukashev, A.N., Bates, P.A., Kulich, P., Leštinová, T., Volf, P., Kostygov, A.Y., Yurchenko, V. The first non-LRV RNA virus in Leishmania. Viruses, 2020, 12: 168. PMID: 32024293
  • Gerasimov, E.S., Zamyatnina, K.A., Matveeva, N.S., Rudenskaya, Y.A., Kraeva, N., Kolesnikov, A.A., Yurchenko, V. Common structural patterns in the maxicircle divergent region of Trypanosomatidae. Pathogens, 2020, 9: 100. PMID: 32033466
  • Horáková, E., Faktorová, D., Kraeva, N., Kaur, B., Van Den Abbeele, J., Yurchenko, V., Lukeš, J. Catalase compromises the development of the insect and mammalian stages of Trypanosoma brucei. FEBS J., 2020, 287: 964-977. PMID: 31593329
  • Sádlová, J., Podešvová, L., Bečvář, T., Bianchi, C., Gerasimov, E.S., Saura, A., Glanzová, K., Leštinová, T., Matveeva, N.S., Chmelová, L., Mlacovská, D., Spitzová, T., Vojtková, B., Volf, P., Yurchenko, V.*, Kraeva, N.* Catalase impairs Leishmania mexicana development and virulence. Virulence, 2021, 12(1): 852-867. * Co-correspondent authors. PMID: 33724149
  • Gerasimov, E.S., Gasparyan, A.A., Afonin, D.A., Zimmer, S.L., Kraeva, N., Lukeš, J., Yurchenko, V., Kolesnikov, A. Complete minicircle genome of Leptomonas pyrrhocoris reveals a source of its non-canonical mitochondrial RNA editing events. Nucl. Acids Res., 2021, 49(6): 3354-3370. PMID: 33660779
  • Chmelová, L’., Bianchi, C., Albanaz, A.T.S., Režnarová, J., Wheeler, R., Kostygov, A.Y., Kraeva, N., Yurchenko, V. Comparative analysis of three trypanosomatid catalases of different origin. Antioxidants, 2022, 11: 46. PMID: 35052550
  • Chmelová, L′.*, Kraeva, N.*, Saura, A., Krayzel, A., Vieira, C.S., Ferreira, T.N., Soares, R.P., Bučková, B., Galan, A., Horáková, E., Vojtková, B., Sádlová, J., Malysheva, M.N., Butenko, A., Prokopchuk, G., Frolov, A.O., Lukeš, J., Horváth, A., Škodová-Sveráková, I., Feder, D., Kostygov, A.Y., Yurchenko, V. Intricate balance of dually-localized catalase modulates infectivity of Leptomonas seymouri (Kinetoplastea: Trypanosomatidae). Int. J. Parasitol., 2024 (in press). * Equal contribution. PMID: 38663543
  • Andreu Saura, Ph.D., postdoctoral researcher

    Education: Institute for Parasitology and Biomedicine “López-Neyra” (IPBLN-CSIC), National Spanish Research Council, Granada, Spain. Ph.D. 2018

    Andreu.jpg

    Publications

  • Sádlová, J., Podešvová, L., Bečvář, T., Bianchi, C., Gerasimov, E.S., Saura, A., Glanzová, K., Leštinová, T., Matveeva, N.S., Chmelová, L., Mlacovská, D., Spitzová, T., Vojtková, B., Volf, P., Yurchenko, V., Kraeva, N. Catalase impairs Leishmania mexicana development and virulence. Virulence, 2021, 12(1): 852-867. PMID: 33724149
  • Rogozin, I.B., Roche-Lima, A., Tyryshkin, K., Carrasquillo-Carrión, K., Lada, A.G., Poliakov, L.Y., Schwartz, E., Saura, A., Yurchenko, V., Cooper, D.N., Panchenko, A.R., Pavlov, Y.I. DNA methylation, deamination and translesion synthesis combine to generate footprint mutations in cancer driver genes in B-cell derived lymphomas and other cancers. Front. Genetics, 2021, 12: 671866. PMID: 34093666
  • Zakharova, A., Saura, A., Butenko, A., Podešvová, L., Warmusová, S., Kostygov,A.Y., Nenarokova, A., Lukeš, J., Opperdoes, F.R., Yurchenko, V. A new model trypanosomatid Novymonas esmeraldas: genomic perception of its "Candidatus Pandoraea novymonadis" endosymbiont. mBio, 2021, 12(4): e01606-21. PMID: 34399629
  • Zakharova, A., Albanaz, A.T.S., Opperdoes, F.R., Škodová-Sveráková, I., Zagirova, D., Saura, A., Chmelová, L’., Gerasimov, E.S., Leštinová, T., Bečvář, T., Sádlová, J., Volf, P., Lukeš, J., Horváth, A., Butenko, A., Yurchenko, V. Leishmania guyanensis M4147 as a new LRV1-bearing model parasite: phosphatidate phosphatase 2-like protein controls cell cycle progression and intracellular lipid content. PLoS Negl. Trop. Dis., 2022, 16(6): e0010510. PMID: 35749562
  • Saura, A.*, Zakharova, A.*, Klocek, D., Gerasimov, E.S., Butenko, A., Macedo, D.H., Servienė, E., Zagirova, D., Meshcheryakova, A., Rogozin, I.B., Serva, S., Kostygov, A.Y., Yurchenko, V. Elimination of LRVs elicits different responses in Leishmania spp. mSphere, 2022, 7(4): e00335-22. * shared contrinution. PMID: 35943162
  • Rogozin, I.B., Saura, A., Bykova, A., Brover, V., Yurchenko, V. Deletions across the SARS-CoV-2 genome: molecular mechanisms and putative functional consequences of deletions in accessory genes. Microorganisms, 2023, 11: 229. PMID: 36677521
  • Zakharova, A., Tashyreva, D., Butenko, A., Morales, J., Saura, A., Svobodová, M., Poschmann, G., Nandipati, S., Zakharova, A., Noyvert, D., Gahura, O., Týč, J., Stühler, K., Kostygov, A.Y., Nowack, E.C.M., Lukeš, J., Yurchenko, V. A neo-functionalized homolog of host transmembrane protein controls localization of bacterial endosymbionts in the trypanosomatid Novymonas esmeraldas. Curr. Biol., 2023, 33(13): 2690-2701. PMID: 37201521
  • Bykova, A., Saura, A., Glazko, G.V., Roche-Lima, A., Yurchenko, V., Rogozin, I.B. The 29-nucleotide deletion in SARS-CoV: truncated versions of ORF8 are under purifying selection. BMC Genomics, 2023, 24(1): 387. PMID: 37430204
  • Usarov, G.X., Turitsin, V.S., Sattarova, X.G., Sádlová, J., ugli Mustanov, J.A., Saura, A., Yurchenko, V. Phlebotomine sand fly (Diptera: Phlebotominae) diversity in the foci of cutaneous leishmaniasis in the Surxondaryo Region of Uzbekistan: 50 years on. Parasitol. Res., 2024, 123: 170. PMID: 38526739
  • Rogozin, I.B., Saura, A., Poliakov, E., Bykova, A., Roche-Lima, A., Pavlov, Y.I., Yurchenko, V. Properties and mechanisms of deletions, insertions, and substitutions in the evolutionary history of SARS-CoV-2. Int. J. Mol. Sci., 2024, 25: 3696. PMID: 38612505
  • Chmelová, L′., Kraeva, N., Saura, A., Krayzel, A., Vieira, C.S., Ferreira, T.N., Soares, R.P., Bučková, B., Galan, A., Horáková, E., Vojtková, B., Sádlová, J., Malysheva, M.N., Butenko, A., Prokopchuk, G., Frolov, A.O., Lukeš, J., Horváth, A., Škodová-Sveráková, I., Feder, D., Kostygov, A.Y., Yurchenko, V. Intricate balance of dually-localized catalase modulates infectivity of Leptomonas seymouri (Kinetoplastea: Trypanosomatidae). Int. J. Parasitol., 2024 (in press). PMID: 38663543
  • Liudmyla Hrebenyk, Ph.D., postdoctoral researcher

    Education: Kharkiv State University. Ph.D. 1996

    Liudmyla Hrebenyk.jpg

    Publications

  • Chmelová, L′., Záhonová, K., Albanaz, A.T.S., Hrebenyk, L., Horváth, A., Yurchenko, V., Škodová-Sveráková, I. Distribution and functional analysis of isocitrate dehydrogenases across kinetoplastids. Genome Biol. Evol., 2024, 16(3): evae042. PMID: 38447055
  • Anzhelika Butenko, Ph.D., postdoctoral researcher (part-time)

    Education: Ostravská Univerzita, Ostrava, Czech Republic. Ph.D. 2017

    Anzhelika Butenko

    Publications

  • Kraeva, N., Butenko, A., Hlaváčová, J., Kostygov, A.Y., Myškova, J., Grybchuk, D., Leštinová, T., Votýpka, J., Volf, P., Opperdoes, F., Flegontov, P., Lukeš, J., Yurchenko, V. Leptomonas seymouri: adaptations to the dixenous life cycle analyzed by genome sequencing, transcriptome profiling and co-infection with Leishmania donovani. PLoS Path., 2015, 11(8): e1005127. PMID: 226317207
  • Flegontov, P.*, Butenko, A.*, Firsov. S., Kraeva, N., Eliáš, M., Field, M., Filatov, D., Flegontova, O., Gerasimov, E., Hlaváčová, J., Ishemgulova, A., Jackson, A., Kelly, S., Kostygov. A.Y., Logacheva, M., Maslov, D., Opperdoes, F., O'Reilly, A., Sádlová, J., Ševčíková, T., Venkatesh, D., Vlček, Č., Volf, P., Votýpka, J., Záhonová, K., Yurchenko, V., Lukeš, J. Genome of Leptomonas pyrrhocoris: a high-quality reference for monoxenous trypanosomatids and new insights into evolution of Leishmania. Sci. Rep., 2016, 6: 23704. * Equal contribution. PMID: 27021793
  • Opperdoes, F.*, Butenko, A.*, Flegontov, P., Yurchenko, V., Lukeš, J. Comparative metabolism of free-living Bodo saltans and parasitic trypanosomatids. J. Euk. Microbiol., 2016, 63(5): 657-678. * Equal contribution. PMID: 27009761
  • Kraeva, N., Horáková, E., Kostygov, A.Y., Kořený, L., Butenko, A., Yurchenko, V., Lukeš, J. Catalase in Leishmaniinae: with me or against me? Infect. Genet. Evol., 2017, 50: 121-127. PMID: 27381333
  • Ishemgulova, A., Butenko, A., Kortišová, L., Boucinha, C., Grybchuk-Ieremenko, A., Morelli, K.A., Tesařová, M., Kraeva, N., Grybchuk, D., Pánek, T., Flegontov, P., Lukeš, J., Votýpka, J., Galvão Pavan, M., Opperdoes, F.R., Spodareva, V., d'Avila-Levy, C., Kostygov, A.Y., Yurchenko, V. Molecular mechanisms of thermal resistance of the insect trypanosomatid Crithidia thermophila. PLoS One, 2017, 12(3): e0174165. PMID: 28328988
  • Ishemgulova, A., Kraeva, N., Hlaváčová, J., Zimmer, S., Butenko, A., Podešvová, L., Leštinová, T., Lukeš, J., Kostygov, A.Y., Votýpka, J., Volf, P., Yurchenko, V.* A putative ATP/GTP binding protein affects Leishmania mexicana growth in insect vectors and vertebrate hosts. PLoS Negl. Trop. Dis., 2017, 11(7): e0005782. PMID: 28742133
  • Lukša, J., Ravoitytė, B., Konovalovas, A., Aitmanaitė, L., Butenko, A., Yurchenko, V., Serva, S., Servienė, E. Different metabolic pathways are involved in response of Saccharomyces cerevisiae to L-A and M viruses. Toxins, 2017, 9: e233. PMID: 28757599
  • Kostygov, A.Y., Butenko, A., Nenarokova, A., Tashyreva, D., Flegontov, P., Lukeš, J., Yurchenko, V. Genome of Ca. Pandoraea novymonadis, an endosymbiotic bacterium of the trypanosomatid Novymonas esmeraldas. Front. Microbiol., 2017, 8: 1940. PMID: 29046673
  • Grybchuk, D., Akopyants. N.S., Kostygov, A.Y., Konovalovas, A., Lye, L.-F., Dobson, D.E., Zangger, H., Fasel. N., Butenko, A., Frolov. A.O., Votýpka, J., d'Avila-Levy, C.M., Kulich, P., Moravcová, J., Plevka, P., Rogozin, I.B., Serva, S., Lukeš, J., Beverley, S.M., Yurchenko, V. Viral discovery and diversity in trypanosomatid protozoa with a focus on relatives of the human parasite Leishmania. Proc. Natl. Acad. Sci. USA, 2018, 115(3): E506-E515. PMID: 29284754
  • Ishemgulova, A., Hlaváčová, J., Majerová, K., Butenko, A., Lukeš, J., Votýpka, J., Volf, P., Yurchenko, V. CRISPR/Cas9 in Leishmania mexicana: a case study of LmxBTN1. PLoS One, 2018, 13(2): e0192723. PMID: 29438445
  • Butenko, A., da Silva Vieira, T., Frolov, A.O., Opperdoes, F.R., Soares, R.P., Kostygov, A.Y., Lukeš, J., Yurchenko, V. Leptomonas pyrrhocoris: genomic insight into parasite's physiology. Curr. Genomics, 2018, 19(2): 150-156. PMID: 29491743
  • Záhonová, K., Petrželková, R., Valach, M., Yazaki, E., Tikhonenkov, D., Butenko, A., Janouškovec, J., Hrdá, Š., Klimeš, V., Burger, G., Inagaki, Y., Keeling, P., Hampl, V., Flegontov, P., Yurchenko, V., Eliáš, M. Extensive molecular tinkering in the evolution of the membrane attachment mode of the Rheb GTPase. Sci. Rep., 2018, 8: 5239. PMID: 29588502
  • Lukeš, J., Butenko, A., Hashimi, H., Maslov, D.A., Votýpka, J., Yurchenko, V. Trypanosomatids are much more than just trypanosomes: clues from the expanded family tree. Trends Parasitol., 2018, 34 (6): 466-480. PMID: 29605546
  • Silva, F., Kostygov, A.Y., Spodareva, V., Butenko, A., Tossou, R., Lukeš, J., Yurchenko, V., Alves, J. The reduced genome of Candidatus Kinetoplastibacterium sorsogonicusi, the endosymbiont of Kentomonas sorsogonicus (Trypanosomatidae): loss of the heme synthesis pathway. Parasitology, 2018, 145(10): 1287-1293. PMID: 29642956
  • Kostygov, A.Y., Butenko, A., Yurchenko, V. On monoxenous trypanosomatids from lesions of immunocompetent patients with suspected cutaneous leishmaniasis in Iran. Trop. Med. Int. Health, 2019, 24(1): 127-128. PMID: 30307678
  • Butenko, A., Kostygov, A.Y., Sádlová, J., Kleschenko, Y., Bečvář, T., Podešvová, L., Macedo, D.H., Žihala, D., Lukeš, J., Bates, P.A., Volf, P., Opperdoes, F.R., Yurchenko, V. Comparative genomics of Leishmania (Mundinia). BMC Genomics, 2019, 20(1): 726. PMID: 31601168
  • Kraeva, N., Leštinová, T., Ishemgulova, A., Majerová, K., Butenko, A., Vaselek, S., Bespyatykh, J., Charyyeva, A., Spitzová, T., Kostygov, A.Y., Lukeš, J., Volf, P., Votýpka, J., Yurchenko, V. LmxM.22.0250-encoded dual specificity protein/lipid phosphatase impairs Leishmania mexicana virulence in vitro. Pathogens, 2019, 8: E241. PMID: 31744234
  • d’Avila-Levy, C.M., Bearzatto, B., Ambroise, J., Helaers, R., Butenko, A., Yurchenko, V., Morelli, K.A., Santos, H.L.C., Brouillard, P., Grellier, P., Gala, J.-L., Vikkula, M. First draft genome of the trypanosomatid Herpetomonas muscarum ingenoplastis through MinION Oxford Nanopore technology and Illumina sequencing. Trop. Med. Infect. Dis., 2020, 5: 25. PMID: 32069939
  • Kostygov, A.Y., Frolov, A.O., Malysheva, M.N., Ganyukova, A.I., Chistyakova, L.V., Tashyreva, D., Tesařová, M., Spodareva, V.V., Režnarová, J., Macedo, D., Butenko, A., d’Avila-Levy, C.M., Lukeš, J., Yurchenko, V. Vickermania gen. nov., trypanosomatids that use two joined flagella to resist midgut peristaltic flow within the fly host. BMC Biol., 2020, 18: 187. PMID: 33267865
  • Durante, I.*, Butenko, A.*, Rašková, V., Charyyeva, A., Svobodová, M., Yurchenko, V., Hashimi, H., Lukeš, J. Large-scale phylogenetic analysis of trypanosomatid adenylate cyclases reveals associations with extracellular lifestyle and host-pathogen interplay. Genome Biol. Evol., 2020, 12(12): 2403-2416. * Equal contribution. PMID: 33104188
  • Opperdoes, F.R., Butenko, A., Zakharova, A., Gerasimov, E.S., Zimmer, S.L., Lukeš, J., Yurchenko, V. The remarkable metabolism of Vickermania ingenoplastis: genomic predictions. Pathogens, 2021, 10: 68. PMID: 33466586
  • Butenko, A., Hammond, M., Field, M., Ginger, M., Yurchenko, V., Lukeš, J. Reductionist pathways for parasitism in euglenozoans? Expanded datasets provide new insights. Trends Parasitol., 2021, 37(2): 100-116. (Review). PMID: 33127331
  • Albanaz, A.T.S., Gerasimov, E.S., Shaw, J.J., Sádlová, J., Lukeš, J., Volf, P., Opperdoes, F.R., Kostygov, A.Y., Butenko, A.*, Yurchenko, V.* Genome analysis of Endotrypanum and Porcisia spp., closest phylogenetic relatives of Leishmania, highlights the role of amastins in shaping pathogenicity. Genes. 2021, 12(3): 444. * Co-correspondent authors. PMID: 33804709
  • Poláková, E., Záhonová, K., Albanaz, A.T.S., Butenko, A., Lukeš, J., Yurchenko, V. Diverse telomeres in trypanosomatids. Parasitology, 2021, 148: 1254-1270. PMID: 33612129
  • Skalický, T., Alves, J.M.P., Morais, A.C., Režnarová, J., Butenko, A., Lukeš, J., Serrano, M.G., Buck, G.A., Teixeira, M.M.G., Camargo, E.P., Sanders, M., Cotton, J.A., Yurchenko, V., Kostygov,A.Y. Endosymbiont capture, a repeated process of endosymbiont transfer with replacement in trypanosomatids Angomonas spp. Pathogens, 2021, 10: 702. PMID: 34200026
  • Zakharova, A., Saura, A., Butenko, A., Podešvová, L., Warmusová, S., Kostygov, A.Y., Nenarokova, A., Lukeš, J., Opperdoes, F.R., Yurchenko, V. A new model trypanosomatid Novymonas esmeraldas: genomic perception of its "Candidatus Pandoraea novymonadis" endosymbiont. mBio, 2021, 12(4): e01606-21. PMID: 34399629
  • Yurchenko, V., Butenko, A., Kostygov, A.Y. Genomics of Trypanosomatidae: where we stand and what needs to be done? Pathogens, 2021, 10: 1124. PMID: 34578156
  • Zakharova, A., Albanaz, A.T.S., Opperdoes, F.R., Škodová-Sveráková, I., Zagirova, D., Saura, A., Chmelová, L’., Gerasimov, E.S., Leštinová, T., Bečvář, T., Sádlová, J., Volf, P., Lukeš, J., Horváth, A., Butenko, A., Yurchenko, V. Leishmania guyanensis M4147 as a new LRV1-bearing model parasite: phosphatidate phosphatase 2-like protein controls cell cycle progression and intracellular lipid content. PLoS Negl. Trop. Dis., 2022, 16(6): e0010510. PMID: 35749562
  • Saura, A., Zakharova, A., Klocek, D., Gerasimov, E.S., Butenko, A., Macedo, D.H., Servienė, E., Zagirova, D., Meshcheryakova, A., Rogozin, I.B., Serva, S., Kostygov, A.Y., Yurchenko, V. Elimination of LRVs elicits different responses in Leishmania spp. mSphere, 2022, 7(4): e00335-22. PMID: 35943162
  • Zakharova, A., Tashyreva, D., Butenko, A., Morales, J., Saura, A., Svobodová, M., Poschmann, G., Nandipati, S., Zakharova, A., Noyvert, D., Gahura, O., Týč, J., Stühler, K., Kostygov, A.Y., Nowack, E.C.M., Lukeš, J., Yurchenko, V. A neo-functionalized homolog of host transmembrane protein controls localization of bacterial endosymbionts in the trypanosomatid Novymonas esmeraldas. Curr. Biol., 2023, 33(13): 2690-2701. PMID: 37201521
  • Albanaz, A.T.S., Butenko, A.*, Kostygov, A.Y., Votýpka, J., Yurchenko, V. Transcriptome of Lafontella sp., an obscure relative of Phytomonas and Herpetomonas. Protistology, 2023, 17(2): 109-117. * Correspondent author.
  • Albanaz, A.T.S., Carrington, M., Frolov, A.O., Ganyukova, A.I., Gerasimov, E.S., Kostygov, A.Y., Lukeš, J., Malysheva, M.N., Votýpka, J., Zakharova, A., Záhonová, K., Zimmer, S.L., Yurchenko, V.*, Butenko, A.* Shining the spotlight on the neglected: new high-quality genome assemblies as a gateway to understanding the evolution of Trypanosomatidae. BMC Genomics, 2023, 24: 471. * Co-correspondent authors. PMID: 37605127
  • Kostygov, A.Y., Albanaz, A.T.S., Butenko, A., Gerasimov, E.S., Lukeš, J., Yurchenko, V. Phylogenetic framework to explore trait evolution in Trypanosomatidae. Trends Parasitol., 2024, 40(2): 96-99. PMID: 38065790
  • Zavataro, A.L.E., Skýpalová, K., Vergara, P.O.T., Silva, F.M, Butenko, A., Yurchenko, V., Kostygov, A.Y., Alves, J.M.P. The genome of the endosymbiont-harboring trypanosomatid Kentomonas sorsogonicus. Protistology, 2024, 18(1): 72-81
  • Chmelová, L′., Kraeva, N., Saura, A., Krayzel, A., Vieira, C.S., Ferreira, T.N., Soares, R.P., Bučková, B., Galan, A., Horáková, E., Vojtková, B., Sádlová, J., Malysheva, M.N., Butenko, A., Prokopchuk, G., Frolov, A.O., Lukeš, J., Horváth, A., Škodová-Sveráková, I., Feder, D., Kostygov, A.Y., Yurchenko, V. Intricate balance of dually-localized catalase modulates infectivity of Leptomonas seymouri (Kinetoplastea: Trypanosomatidae). Int. J. Parasitol., 2024 (in press). PMID: 38663543
  • Grybchuk, D., Galan, A., Klocek, D., Macedo, D.H., Wolf, Y.I., Votýpka, J., Butenko, A., Lukeš, J., Neri, U., Záhonová, K., Kostygov, A.Y., Koonin, E.V., Yurchenko, V. Identification of diverse RNA viruses in Obscuromonas flagellates (Euglenozoa: Trypanosomatidae: Blastocrithidiinae). Virus Evol., 2024 (in press). PMID:
  • Kristína Pašuthová (Záhonová), Ph.D., postdoctoral researcher (part-time)

    Education: Ostravská Univerzita, Ostrava, Czech Republic. Ph.D. 2016

    Kristína Pašuthová

    Publications

  • Záhonová, K., Hadariová, L., Vacula, R., Yurchenko, V., Eliáš, M., Krajčovič, J., Vesteg, M. A small portion of plastid transcripts is polyadenylated in the flagellate Euglena gracilis. FEBS Lett., 2014, 588: 783-788. PMID: 24492004
  • Flegontov, P., Butenko, A., Firsov. S., Kraeva, N., Eliáš, M., Field, M., Filatov, D., Flegontova, O., Gerasimov, E., Hlaváčová, J., Ishemgulova, A., Jackson, A., Kelly, S., Kostygov. A.Y., Logacheva, M., Maslov, D., Opperdoes, F., O'Reilly, A., Sádlová, J., Ševčíková, T., Venkatesh, D., Vlček, Č., Volf, P., Votýpka, J., Záhonová, K., Yurchenko, V., Lukeš, J. Genome of Leptomonas pyrrhocoris: a high-quality reference for monoxenous trypanosomatids and new insights into evolution of Leishmania. Sci. Rep., 2016, 6: 23704. PMID: 27021793
  • Záhonová, K., Füssy, Z., Oborník, M., Eliáš, M., Yurchenko, V. RuBisCO in non-photosynthetic alga Euglena longa: divergent features, transcriptomic analysis and regulation of complex formation. PLoS One, 2016, 11(7): e0158790. PMID: 27391690
  • Záhonová, K.*, Kostygov, A.Y.*, Ševčíková, T., Yurchenko, V., Eliáš, M. An unprecedented non-canonical nuclear genetic code with all three termination codons reassigned as sense codons. Curr. Biol., 2016, 26: 2364-2369. * Equal contribution. PMID: 27593378
  • Záhonová, K., Petrželková, R., Valach, M., Yazaki, E., Tikhonenkov, D., Butenko, A., Janouškovec, J., Hrdá, Š., Klimeš, V., Burger, G., Inagaki, Y., Keeling, P., Hampl, V., Flegontov, P., Yurchenko, V., Eliáš, M. Extensive molecular tinkering in the evolution of the membrane attachment mode of the Rheb GTPase. Sci. Rep., 2018, 8: 5239. PMID: 29588502
  • Nenarokova, A., Záhonová, K., Krasilnikova, M., Gahura, O., McCulloch, R., Zíková, A., Yurchenko, V., Lukeš, J. Causes and effects of loss of classical non-homologous end joining pathway in parasitic eukaryotes. mBio, 2019, 10(4): e01541-19. PMID: 31311886
  • Bianchi, C., Kostygov, A.Y., Kraeva, N., Záhonová, K., Horáková, E., Sobotka, R., Lukeš, J., Yurchenko, V. An enigmatic catalase of Blastocrithidia. Mol. Biohem. Parasitol., 2019, 232: 111199. PMID: 31276694
  • Škodová-Sveráková, I.*, Záhonová, K.*, Bučková, B., Füssy, Z., Yurchenko, V., Lukeš, J. Catalase and ascorbate peroxidase in euglenozoan protists. Pathogens, 2020, 9: 317.* Equal contribution. PMID: 32344595
  • Füssy, Z.*, Záhonová, K.*, Tomčala, A., Krajčovič, J., Yurchenko, V., Oborník, M., Eliáš, M. The cryptic plastid of Euglena longa defines a new type of nonphotosynthetic plastid organelles. mSphere, 2020, 5(5): e00675-20. * Equal contribution. PMID: 33087518
  • Poláková, E., Záhonová, K., Albanaz, A.T.S., Butenko, A., Lukeš, J., Yurchenko, V. Diverse telomeres in trypanosomatids. Parasitology, 2021, 148: 1254-1270. PMID: 33612129
  • Kachale, A., Pavlíková, Z., Nenarokova, A., Roithová, A., Durante, I.M., Miletínová, P., Záhonová, K., Nenarokov, S., Votýpka, J., Horáková, E., Ross, R.L., Yurchenko, V., Beznosková, P., Paris, Z., Valášek, L.S., Lukeš, J. Short tRNA anticodon stem and mutant eRF1 allow stop codon reassignment. Nature, 2023, 613(7945): 751-758. PMID: 36631608
  • Albanaz, A.T.S., Carrington, M., Frolov, A.O., Ganyukova, A.I., Gerasimov, E.S., Kostygov, A.Y., Lukeš, J., Malysheva, M.N., Votýpka, J., Zakharova, A., Záhonová, K., Zimmer, S.L., Yurchenko, V., Butenko, A. Shining the spotlight on the neglected: new high-quality genome assemblies as a gateway to understanding the evolution of Trypanosomatidae. BMC Genomics, 2023, 24: 471. PMID: 37605127
  • Macedo, D.H., Grybchuk, D., Režnarová, J., Votýpka, J., Klocek, D., Yurchenko, T., Ševčík, J., Magri, A., Urda Dolinská, M., Záhonová, K., Lukeš, J., Servienė, E., Jászayová, A., Serva, S., Malysheva, M.N., Frolov, A.O., Yurchenko, V., Kostygov, A.Y. Diversity of RNA viruses in the cosmopolitan monoxenous trypanosomatid Leptomonas pyrrhocoris. BMC Biol., 2023, 21(1): 191. PMID: 37697369
  • Opperdoes, F.R.*, Záhonová, K.*, Škodová-Sveráková, I.*, Bučková, B., Chmelová, L′., Lukeš, J., Yurchenko, V. In silico prediction of the metabolism of Blastocrithidia nonstop, a trypanosomatid with non-canonical genetic code. BMC Genomics, 2024, 25(1): 184. * Equal contribution. PMID: 38365628
  • Chmelová, L′., Záhonová, K., Albanaz, A.T.S., Hrebenyk, L., Horváth, A., Yurchenko, V., Škodová-Sveráková, I. Distribution and functional analysis of isocitrate dehydrogenases across kinetoplastids. Genome Biol. Evol., 2024, 16(3): evae042. PMID: 38447055
  • Afonin, D.A., Gerasimov, E.S., Škodová-Sveráková, I., Záhonová, K., Gahura, O., Albanaz, A.T.S., Myšková, E., Bykova, A., Paris, Z., Lukeš, J., Opperdoes, F.R., Horváth, A., Zimmer, S.L., Yurchenko, V. Blastocrithidia nonstop mitochondrial genome and its expression are remarkably insulated from nuclear codon reassignment. Nucl. Acids Res., 2024, 52: 3870–3885. PMID: 38452217
  • Grybchuk, D., Galan, A., Klocek, D., Macedo, D.H., Wolf, Y.I., Votýpka, J., Butenko, A., Lukeš, J., Neri, U., Záhonová, K., Kostygov, A.Y., Koonin, E.V., Yurchenko, V. Identification of diverse RNA viruses in Obscuromonas flagellates (Euglenozoa: Trypanosomatidae: Blastocrithidiinae). Virus Evol., 2024 (in press). PMID:
  • Danil Grybchuk, Ph.D., postdoctoral researcher (part-time)

    Education: Ostravská Univerzita, Ostrava, Czech Republic. Ph.D. 2017

    Danil Grybchuk

    Publications

  • Votýpka, J., Kostygov, A.Y., Kraeva, N., Grybchuk-Ieremenko, A., Tesařová, M., Grybchuk, D., Lukeš, J., Yurchenko, V. Kentomonas gen. n., a new genus of endosymbiont-containing trypanosomatids of Strigomonadinae subfam. n. Protist, 2014, 165: 825-838. PMID: 25460233
  • Kraeva, N., Butenko, A., Hlaváčová, J., Kostygov, A.Y., Myškova, J., Grybchuk, D., Leštinová, T., Votýpka, J., Volf, P., Opperdoes, F., Flegontov, P., Lukeš, J., Yurchenko, V. Leptomonas seymouri: adaptations to the dixenous life cycle analyzed by genome sequencing, transcriptome profiling and co-infection with Leishmania donovani. PLoS Path., 2015, 11(8): e1005127. PMID: 226317207
  • Ishemgulova, A., Butenko, A., Kortišová, L., Boucinha, C., Grybchuk-Ieremenko, A., Morelli, K.A., Tesařová, M., Kraeva, N., Grybchuk, D., Pánek, T., Flegontov, P., Lukeš, J., Votýpka, J., Galvão Pavan, M., Opperdoes, F.R., Spodareva, V., d'Avila-Levy, C., Kostygov, A.Y., Yurchenko, V. Molecular mechanisms of thermal resistance of the insect trypanosomatid Crithidia thermophila. PLoS One, 2017, 12(3): e0174165. PMID: 28328988
  • Grybchuk, D., Akopyants. N.S., Kostygov, A.Y., Konovalovas, A., Lye, L.-F., Dobson, D.E., Zangger, H., Fasel. N., Butenko, A., Frolov. A.O., Votýpka, J., d'Avila-Levy, C.M., Kulich, P., Moravcová, J., Plevka, P., Rogozin, I.B., Serva, S., Lukeš, J., Beverley, S.M., Yurchenko, V. Viral discovery and diversity in trypanosomatid protozoa with a focus on relatives of the human parasite Leishmania. Proc. Natl. Acad. Sci. USA, 2018, 115(3): E506-E515. PMID: 29284754
  • Grybchuk, D., Kostygov, A.Y., Macedo, D.H., d'Avila-Levy, C.M., Yurchenko, V. RNA viruses in trypanosomatid parasites: a historical overview (Review). Mem. Inst. Oswaldo Cruz, 2018, 113(4): e170487. PMID: 29513877
  • Grybchuk, D., Kostygov, A.Y., Macedo, D.H., Votýpka, J., Lukeš, J., Yurchenko, V. RNA viruses in Blechomonas (Trypanosomatidae) and evolution of Leishmaniavirus. mBio, 2018, 9(5): e01932-18. PMID: 30327446
  • Kleschenko, Y.*, Grybchuk, D.*, Matveeva, N.S., Macedo, D.H., Ponirovsky, E.N., Lukashev, A.N., Yurchenko, V. Molecular characterization of LRV2 in Leishmania major from Uzbekistan. Genes, 2019, 10: E830. * Equal contribution. PMID: 31640177
  • Grybchuk, D.*, Macedo, D.H.*, Kleschenko, Y., Kraeva, N., Lukashev, A.N., Bates, P.A., Kulich, P., Leštinová, T., Volf, P., Kostygov, A.Y., Yurchenko, V. The first non-LRV RNA virus in Leishmania. Viruses, 2020, 12: 168. * Equal contribution. PMID: 32024293
  • Procházková, M., Füzik, T., Grybchuk, D., Falginella, F., Podešvová, L., Yurchenko, V., Vácha, R., Plevka, P. Capsid structure of Leishmania RNA virus 1. J. Virol., 2021, 95(3): e01957-20. PMID: 33208443
  • Kostygov, A.Y.*; Grybchuk, D.*, Kleschenko, Y., Chistyakov, D.S., Lukashev, A.N., Gerasimov, E.S., Yurchenko, V. Analyses of Leishmania-LRV co-phylogenetic patterns and evolutionary variability of viral proteins. Viruses, 2021, 13(11): 2305. * Equal contribution. PMID: 34835111
  • Grybchuk, D., Procházková, M., Füzik, T., Konovalovas, A., Serva, S., Yurchenko, V., Plevka, P. Structures of L-BC virus and its open particle provide insight into Totivirus capsid assembly. Commun. Biol., 2022, 5(1): 847. PMID: 35986212
  • Procházková, M., Füzik, T., Grybchuk, D., Yurchenko, V., Plevka, P. Virion structure of Leishmania RNA virus 1. Virology, 2022, 577: 149-154. PMID: 36371873
  • Klocek, D., Grybchuk, D., Tichá, L., Votýpka, J., Volf, P., Kostygov, A.Y., Yurchenko, V. Evolution of RNA viruses in trypanosomatids: new insights from the analysis of Sauroleishmania. Parasitol. Res., 2023, 122(10): 2279-2286. PMID: 37490143
  • Dutra-Rêgo, F., da Silva, E.S., Lopes, V.V., Teixeira-Neto, R.G., Belo, V.S., Fonseca Júnior, A.A., Pereira, D.A., Pena, H.P., Laurenti, M.D., Flores, G.V.A., da Matta, V.L.R., Chouman, I.H., Burrin, T.B., Pacheco, C.M.S., Barrouin-Melo, S.M., de Pinho, F.A., de Andrade, H.A., Nunes, R.V., Gontijo, C.M.F., Soccol, V.T., Klocek, D., Grybchuk, D., Macedo, D.H., do Monte-Neto, R.L., Yurchenko, V., Soares, R.P. First report of putative Leishmania RNA virus 2 (LRV2) in Leishmania infantum strains from canine and human visceral leishmaniasis cases in the Southeast of Brazil. Mem. Inst. Oswaldo Cruz, 2023, 118: e230071. PMID: 37729273
  • Macedo, D.H., Grybchuk, D., Režnarová, J., Votýpka, J., Klocek, D., Yurchenko, T., Ševčík, J., Magri, A., Urda Dolinská, M., Záhonová, K., Lukeš, J., Servienė, E., Jászayová, A., Serva, S., Malysheva, M.N., Frolov, A.O., Yurchenko, V., Kostygov, A.Y. Diversity of RNA viruses in the cosmopolitan monoxenous trypanosomatid Leptomonas pyrrhocoris. BMC Biol., 2023, 21(1): 191. PMID: 37697369
  • Klocek, D., Grybchuk, D., Macedo, D.H., Galan, A., Votýpka, J., Schmid-Hempel, R., Schmid-Hempel, P., Yurchenko, V., Kostygov, A.Y. RNA viruses of Crithidia bombi, a parasite of bumblebees. J. Invertebr. Pathol., 2023, 201: 107991. PMID: 37714407
  • Grybchuk, D., Galan, A., Klocek, D., Macedo, D.H., Wolf, Y.I., Votýpka, J., Butenko, A., Lukeš, J., Neri, U., Záhonová, K., Kostygov, A.Y., Koonin, E.V., Yurchenko, V. Identification of diverse RNA viruses in Obscuromonas flagellates (Euglenozoa: Trypanosomatidae: Blastocrithidiinae). Virus Evol., 2024 (in press). PMID:
  • Grybchuk, D., Kostygov, A.Y., Yurchenko, V. Analysis of Leishbuviridae from trypanosomatids. In: Bunyaviruses: Methods and Protocols (Ed. H. Boshra), 2024, (in press). (ISBN "Methods in Molecular Biology " Series xxx, ISBN xxx).
  • Ingrid Škodová-Sveráková, Ph.D., postdoctoral researcher (part-time)

    Education: Univerzita Komenského v Bratislave, Bratislava, Slovakia. Ph.D. 2014

    Ingrid Škodová-Sveráková

    Publications

  • Škodová-Sveráková, I.*, Záhonová, K.*, Bučková, B., Füssy, Z., Yurchenko, V., Lukeš, J. Catalase and ascorbate peroxidase in euglenozoan protists. Pathogens, 2020, 9: 317. * Equal contribution. PMID: 32344595
  • Zakharova, A., Albanaz, A.T.S., Opperdoes, F.R., Škodová-Sveráková, I., Zagirova, D., Saura, A., Chmelová, L’., Gerasimov, E.S., Leštinová, T., Bečvář, T., Sádlová, J., Volf, P., Lukeš, J., Horváth, A., Butenko, A., Yurchenko, V. Leishmania guyanensis M4147 as a new LRV1-bearing model parasite: phosphatidate phosphatase 2-like protein controls cell cycle progression and intracellular lipid content. PLoS Negl. Trop. Dis., 2022, 16(6): e0010510. PMID: 35749562
  • Opperdoes, F.R.*, Záhonová, K.*, Škodová-Sveráková, I.*, Bučková, B., Chmelová, L′., Lukeš, J., Yurchenko, V. In silico prediction of the metabolism of Blastocrithidia nonstop, a trypanosomatid with non-canonical genetic code. BMC Genomics, 2024, 25(1): 184. * Equal contribution. PMID: 38365628
  • Chmelová, L′., Záhonová, K., Albanaz, A.T.S., Hrebenyk, L., Horváth, A., Yurchenko, V.*, Škodová-Sveráková, I.* Distribution and functional analysis of isocitrate dehydrogenases across kinetoplastids. Genome Biol. Evol., 2024, 16(3) evae042. * Co-correspondent authors. PMID: 38447055
  • Afonin, D.A., Gerasimov, E.S., Škodová-Sveráková, I., Záhonová, K., Gahura, O., Albanaz, A.T.S., Myšková, E., Bykova, A., Paris, Z., Lukeš, J., Opperdoes, F.R., Horváth, A., Zimmer, S.L., Yurchenko, V. Blastocrithidia nonstop mitochondrial genome and its expression are remarkably insulated from nuclear codon reassignment. Nucl. Acids Res., 2024, 52: 3870–3885. PMID: 38452217
  • Chmelová, L′., Kraeva, N., Saura, A., Krayzel, A., Vieira, C.S., Ferreira, T.N., Soares, R.P., Bučková, B., Galan, A., Horáková, E., Vojtková, B., Sádlová, J., Malysheva, M.N., Butenko, A., Prokopchuk, G., Frolov, A.O., Lukeš, J., Horváth, A., Škodová-Sveráková, I., Feder, D., Kostygov, A.Y., Yurchenko, V. Intricate balance of dually-localized catalase modulates infectivity of Leptomonas seymouri (Kinetoplastea: Trypanosomatidae). Int. J. Parasitol., 2024 (in press). PMID: 38663543
  • PhD students

    Msc. Viktoria Spodareva, PhD student

    Education: Kalmyk State University, Elista, Russia. MSc. 2001

    Viktoria Spodareva

    Publications

  • Ishemgulova, A., Butenko, A., Kortišová, L., Boucinha, C., Grybchuk-Ieremenko, A., Morelli, K.A., Tesařová, M., Kraeva, N., Grybchuk, D., Pánek, T., Flegontov, P., Lukeš, J., Votýpka, J., Galvão Pavan, M., Opperdoes, F.R., Spodareva, V., d'Avila-Levy, C., Kostygov, A., Yurchenko, V. Molecular mechanisms of thermal resistance of the insect trypanosomatid Crithidia thermophila. PLoS One, 2017, 12(3): e0174165. PMID: 28328988
  • Silva, F., Kostygov, A., Spodareva, V., Butenko, A., Tossou, R., Lukeš, J., Yurchenko, V., Alves, J. The reduced genome of Candidatus Kinetoplastibacterium sorsogonicusi, the endosymbiont of Kentomonas sorsogonicus (Trypanosomatidae): loss of the heme synthesis pathway. Parasitology, 2018, 145(10): 1287-1293. PMID: 29642956
  • Spodareva, V., Grybchuk-Ieremenko, A., Losev, A., Votýpka, J., Lukeš, J., Yurchenko, V., Kostygov, A. Diversity and evolution of anuran trypanosomes: insights from the study of European species. Parasit. Vectors, 2018, 11: 447. PMID: 30071897
  • Frolov, A.O, Malysheva, M.N., Ganyukova, A.I., Spodareva, V., Yurchenko, V., Kostygov, A.Y. Development of Phytomonas lipae sp. n. (Kinetoplastea: Trypanosomatidae) in the true bug Coreus marginatus (Heteroptera: Coreidae) and insights into the evolution of life cycles in the genus Phytomonas. PLoS One, 2019, 14(4): e0214484. PMID: 30943229
  • Frolov, A.O., Malysheva, M.N., Ganyukova, A.I., Spodareva, V.V., Králová, J., Yurchenko, V., Kostygov, A.Y. If host is refractory, insistent parasite goes berserk: trypanosomatid Blastocrithidia raabei in the true bug Coreus marginatus. PLoS One, 2020, 15(1): e0227832. PMID: 31945116
  • Ganyukova, A.I., Frolov, A.O., Malysheva, M.N., Spodareva, V.V., Yurchenko, V., Kostygov, A.Y. A novel endosymbiont-containing trypanosomatid Phytomonas borealis sp. n. from the predatory bug Picromerus bidens (Heteroptera, Pentatomidae). Folia Parasitol., 2020, 67: 004. PMID: 32350156
  • Kostygov, A.Y., Frolov, A.O., Malysheva, M.N., Ganyukova, A.I., Chistyakova, L.V., Tashyreva, D., Tesařová, M., Spodareva, V.V., Režnarová, J., Macedo, D., Butenko, A., d’Avila-Levy, C.M., Lukeš, J., Yurchenko, V. Vickermania gen. nov., trypanosomatids that use two joined flagella to resist midgut peristaltic flow within the fly host. BMC Biol., 2020, 18: 187. PMID: 33267865
  • Mgr. Ester Poláková, PhD student

    Education: Ostravská Univerzita, Ostrava, Czech Republic. Mgr. 2018

    Ester Poláková

    Publications

  • Poláková, E., Záhonová, K., Albanaz, A.T.S., Butenko, A., Lukeš, J., Yurchenko, V. Diverse telomeres in trypanosomatids. Parasitology, 2021, 148: 1254-1270. PMID: 33612129
  • Poláková, E., Albanaz, A.T.S., Zakharova, A., Novozhilova, T.S., Gerasimov, E.S., Yurchenko, V. Ku80 is involved in telomere maintenance but dispensable for genomic stability in Leishmania mexicana. PLoS Negl. Trop. Dis., 2021, 15(12): e0010041. PMID: 34965251
  • Ennes-Vidal, V., Antunes, D., Poláková, E., Yurchenko, V., Oliveira, S.S.C., Faria da Mota, F., Guimaraes, A.C.R., Caffarena, E.R., Santos , A.L.S, Branquinha, M.H., d’Avila-Levy, C.M. Differences in charge distribution in Leishmania tarentolae leishmanolysin result in a reduced enzymatic activity. Int. J. Mol. Sci., 2022, 23: 7660. PMID: 35887004
  • Msc. Anastassia Bykova, PhD student

    Education: Moscow State University, Moscow, Russia. MSc. 2020

    Anastassia Bykova

    Publications

  • Belinky, F., Bykova, A. , Yurchenko, V., Rogozin, I. B. No evidence for widespread positive selection on double substitutions within codons in primates and yeasts. Front. Genetics, 2022, 13: 991249. PMID: 36159983
  • Rogozin, I.B., Saura, A., Bykova, A., Brover, V., Yurchenko, V. Deletions across the SARS-CoV-2 genome: molecular mechanisms and putative functional consequences of deletions in accessory genes. Microorganisms, 2023, 11: 229. PMID: 36677521
  • Bykova, A., Saura, A., Glazko, G.V., Roche-Lima, A., Yurchenko, V., Rogozin, I.B. The 29-nucleotide deletion in SARS-CoV: truncated versions of ORF8 are under purifying selection. BMC Genomics, 2023, 24(1): 387. PMID: 37430204
  • Afonin, D.A., Gerasimov, E.S., Škodová-Sveráková, I., Záhonová, K., Gahura, O., Albanaz, A.T.S., Myšková, E., Bykova, A., Paris, Z., Lukeš, J., Opperdoes, F.R., Horváth, A., Zimmer, S.L., Yurchenko, V. Blastocrithidia nonstop mitochondrial genome and its expression are remarkably insulated from nuclear codon reassignment. Nucl. Acids Res., 2024, 52: 3870–3885. PMID: 38452217
  • Rogozin, I.B., Saura, A., Poliakov, E., Bykova, A., Roche-Lima, A., Pavlov, Y.I., Yurchenko, V. Properties and mechanisms of deletions, insertions, and substitutions in the evolutionary history of SARS-CoV-2. Int. J. Mol. Sci., 2024, 25: 3696. PMID: 38612505
  • Mgr. Ľubomíra Chmelová, PhD student

    Education: Univerzita Komenského v Bratislave, Bratislava, Slovakia. Mgr. 2020

    Ľubomíra Chmelová

    Publications

  • Sádlová, J., Podešvová, L., Bečvář, T., Bianchi, C., Gerasimov, E.S., Saura, A., Glanzová, K., Leštinová, T., Matveeva, N.S., Chmelová, L., Mlacovská, D., Spitzová, T., Vojtková, B., Volf, P., Yurchenko, V., Kraeva, N. Catalase impairs Leishmania mexicana development and virulence. Virulence, 2021, 12(1): 852-867. PMID: 33724149
  • Chmelová, L’.*, Bianchi, C.*, Albanaz, A.T.S., Režnarová, J., Wheeler, R., Kostygov, A.Y., Kraeva, N., Yurchenko, V. Comparative analysis of three trypanosomatid catalases of different origin. Antioxidants, 2022, 11: 46. * shared contribution. PMID: 35052550
  • Zakharova, A., Albanaz, A.T.S., Opperdoes, F.R., Škodová-Sveráková, I., Zagirova, D., Saura, A., Chmelová, L’., Gerasimov, E.S., Leštinová, T., Bečvář, T., Sádlová, J., Volf, P., Lukeš, J., Horváth, A., Butenko, A., Yurchenko, V. Leishmania guyanensis M4147 as a new LRV1-bearing model parasite: phosphatidate phosphatase 2-like protein controls cell cycle progression and intracellular lipid content. PLoS Negl. Trop. Dis., 2022, 16(6): e0010510. PMID: 35749562
  • Magri, A., Bianchi, C., Chmelová, L′., Caffara, M., Galuppi, R., Fioravanti, M., Yurchenko, V., Kostygov, A.Y. Roe deer (Capreolus capreolus) are a novel potential reservoir for human visceral leishmaniasis in the Emilia-Romagna region of Northeastern Italy. Int. J. Parasitol., 2022, 52(12): 745-750. PMID: 36265672
  • Kostygov, A.Y., Chmelová, L′., Reichl, J., Jászayová, A., Votýpka, J., Fuehrer, H.-P., Yurchenko, V. Parasites of firebugs in Austria with focus on the "micro"-diversity of the cosmopolitan trypanosomatid Leptomonas pyrrhocoris. Parasitol. Res., 2024, 123(1): 27. PMID: 38072883
  • Opperdoes, F.R., Záhonová, K., Škodová-Sveráková, I., Bučková, B., Chmelová, L′., Lukeš, J., Yurchenko, V. In silico prediction of the metabolism of Blastocrithidia nonstop, a trypanosomatid with non-canonical genetic code. BMC Genomics, 2024, (25(1): 184. PMID: 38365628
  • Chmelová, L′., Záhonová, K., Albanaz, A.T.S., Hrebenyk, L., Horváth, A., Yurchenko, V., Škodová-Sveráková, I. Distribution and functional analysis of isocitrate dehydrogenases across kinetoplastids. Genome Biol. Evol., 2024, 16(3): evae042. PMID: 38447055
  • Chmelová, L′.*, Kraeva, N.*, Saura, A., Krayzel, A., Vieira, C.S., Ferreira, T.N., Soares, R.P., Bučková, B., Galan, A., Horáková, E., Vojtková, B., Sádlová, J., Malysheva, M.N., Butenko, A., Prokopchuk, G., Frolov, A.O., Lukeš, J., Horváth, A., Škodová-Sveráková, I., Feder, D., Kostygov, A.Y., Yurchenko, V. Intricate balance of dually-localized catalase modulates infectivity of Leptomonas seymouri (Kinetoplastea: Trypanosomatidae). Int. J. Parasitol., 2024 (in press). * Equal contribution. PMID: 38663543
  • Msc. Arnau Galan Rigol, PhD student

    Education: Universitat de Barcelona, Barcelona, Spain. MSc. 2021

    Arnau Galan Rigol

    Publications

  • Klocek, D., Grybchuk, D., Macedo, D.H., Galan, A., Votýpka, J., Schmid-Hempel, R., Schmid-Hempel, P., Yurchenko, V., Kostygov, A.Y. RNA viruses of Crithidia bombi, a parasite of bumblebees. J. Invertebr. Pathol., 2023, 201: 107991. PMID: 37714407
  • Chmelová, L′., Kraeva, N., Saura, A., Krayzel, A., Vieira, C.S., Ferreira, T.N., Soares, R.P., Bučková, B., Galan, A., Horáková, E., Vojtková, B., Sádlová, J., Malysheva, M.N., Butenko, A., Prokopchuk, G., Frolov, A.O., Lukeš, J., Horváth, A., Škodová-Sveráková, I., Feder, D., Kostygov, A.Y., Yurchenko, V. Intricate balance of dually-localized catalase modulates infectivity of Leptomonas seymouri (Kinetoplastea: Trypanosomatidae). Int. J. Parasitol., 2024 (in press). PMID: 38663543
  • Grybchuk, D., Galan, A., Klocek, D., Macedo, D.H., Wolf, Y.I., Votýpka, J., Butenko, A., Lukeš, J., Neri, U., Záhonová, K., Kostygov, A.Y., Koonin, E.V., Yurchenko, V. Identification of diverse RNA viruses in Obscuromonas flagellates (Euglenozoa: Trypanosomatidae: Blastocrithidiinae). Virus Evol., 2024 (in press). PMID:
  • Msc. Donnamae Klocek

    Education: Massey University, New Zealand. MSc. 2023

    onnamae Klocek

    Publications

  • Saura, A., Zakharova, A., Klocek, D., Gerasimov, E.S., Butenko, A., Macedo, D.H., Servienė, E., Zagirova, D., Meshcheryakova, A., Rogozin, I.B., Serva, S., Kostygov, A.Y., Yurchenko, V. Elimination of LRVs elicits different responses in Leishmania spp. mSphere, 2022, 7(4): e00335-22. PMID: 35943162
  • Klocek, D., Grybchuk, D., Tichá, L., Votýpka, J., Volf, P., Kostygov, A.Y., Yurchenko, V. Evolution of RNA viruses in trypanosomatids: new insights from the analysis of Sauroleishmania. Parasitol. Res., 2023, 122(10): 2279-2286. PMID: 37490143
  • Macedo, D.H., Grybchuk, D., Režnarová, J., Votýpka, J., Klocek, D., Yurchenko, T., Ševčík, J., Magri, A., Urda Dolinská, M., Záhonová, K., Lukeš, J., Servienė, E., Jászayová, A., Serva, S., Malysheva, M.N., Frolov, A.O., Yurchenko, V., Kostygov, A.Y. Diversity of RNA viruses in the cosmopolitan monoxenous trypanosomatid Leptomonas pyrrhocoris. BMC Biol., 2023, 21(1): 191. PMID: 37697369
  • Dutra-Rêgo, F., da Silva, E.S., Lopes, V.V., Teixeira-Neto, R.G., Belo, V.S., Fonseca Júnior, A.A., Pereira, D.A., Pena, H.P., Laurenti, M.D., Flores, G.V.A., da Matta, V.L.R., Chouman, I.H., Burrin, T.B., Pacheco, C.M.S., Barrouin-Melo, S.M., de Pinho, F.A., de Andrade, H.A., Nunes, R.V., Gontijo, C.M.F., Soccol, V.T., Klocek, D., Grybchuk, D., Macedo, D.H., do Monte-Neto, R.L., Yurchenko, V., Soares, R.P. First report of putative Leishmania RNA virus 2 (LRV2) in Leishmania infantum strains from canine and human visceral leishmaniasis cases in the Southeast of Brazil. Mem. Inst. Oswaldo Cruz, 2023, 118: e230071. PMID: 37729273
  • Klocek, D., Grybchuk, D., Macedo, D.H., Galan, A., Votýpka, J., Schmid-Hempel, R., Schmid-Hempel, P., Yurchenko, V., Kostygov, A.Y. RNA viruses of Crithidia bombi, a parasite of bumblebees. J. Invertebr. Pathol., 2023, 201: 107991. PMID: 37714407
  • Grybchuk, D., Galan, A., Klocek, D., Macedo, D.H., Wolf, Y.I., Votýpka, J., Butenko, A., Lukeš, J., Neri, U., Záhonová, K., Kostygov, A.Y., Koonin, E.V., Yurchenko, V. Identification of diverse RNA viruses in Obscuromonas flagellates (Euglenozoa: Trypanosomatidae: Blastocrithidiinae). Virus Evol., 2024 (in press). PMID:
  • Mgr. Adam Krayzel (under tutelage of Dr. Kraeva)

    Education: Ostravská Univerzita, Ostrava, Czech Republic. Mgr. 2023

    Adam Krayzel

    Publications

  • Chmelová, L′., Kraeva, N., Saura, A., Krayzel, A., Vieira, C.S., Ferreira, T.N., Soares, R.P., Bučková, B., Galan, A., Horáková, E., Vojtková, B., Sádlová, J., Malysheva, M.N., Butenko, A., Prokopchuk, G., Frolov, A.O., Lukeš, J., Horváth, A., Škodová-Sveráková, I., Feder, D., Kostygov, A.Y., Yurchenko, V. Intricate balance of dually-localized catalase modulates infectivity of Leptomonas seymouri (Kinetoplastea: Trypanosomatidae). Int. J. Parasitol., 2024 (in press). PMID: 38663543
  • Msc. Elora Kalita

    Education: Central University of Rajasthan, Ajmer, India. MSc. 2022

    Elora Kalita

    Mgr. Karolína Skýpalová (under tutelage of Dr. Kostygov)

    Education: Ostravská Univerzita, Ostrava, Czech Republic. Mgr. 2023

    Karolína Skýpalová

    Publications

  • Zavataro, A.L.E.*, Skýpalová, K.*, Vergara, P.O.T., Silva, F.M, Butenko, A., Yurchenko, V., Kostygov, A.Y., Alves, J.M.P. The genome of the endosymbiont-harboring trypanosomatid Kentomonas sorsogonicus. Protistology, 2024, 18(1): 72-81. * Equal contribution.
  • Msc. Aditya Reddy

    Education: Central University of Kerala, India. Msc. 2019

    Aditya Reddy

    Master students

    BSc. Martina Byrtusová (under tutelage of Dr. Kraeva)

    Education: Ostravská Univerzita, Ostrava, Czech Republic. BSc. 2023

    Lab alumni, postdocs

    Dr. Aleksander Losev

    2015

    Dr. Claretta Bianchi

    2022

    Lab alumni, Ph.D. students

    Dr. Natalya Kraeva

    2017, Ph.D. thesis: "Analysis of genetic differences between monoxenous and dixenous Leishmaniinae for identification of novel virulence factors"

    Dr. Anastasiia Grybchuk-Ieremenko

    2017, Ph.D. thesis: "Diversity and molecular phylogeny of monoxenous insect trypanosomatids and trypanosomes from freshwater vertebrates"

    Dr. Aygul Ishemgulova

    2017, Ph.D. thesis: "Functional genomics of Leishmania virulence"

    Dr. Danyil Grybchuk

    2017, Ph.D. thesis: "Diversity and phylogeny of RNA viruses in Trypanosomatidae with insights into viral ecology and host cell interaction"

    Dr. Lucie Podešvová

    2020, Ph.D. thesis: "The new molecular tools for Leishmania research"

    Dr. Diego Henrique Fagundes Macedo

    2021, Ph.D. thesis: "Jumping on the viral bandwagon: a study on the diversity and evolution of RNA viruses in trypanosomatids with the emphasis on leishmaniaviruses"

    Dr. Jana Režnarová (Králová) (supervised by Dr. Alexei Kostygov)

    2021, Ph.D. thesis: "Diversity and biology of monoxenous trypanosomatids on a broad and specific scale"

    Dr. Arzuv Charyyeva

    2021, Ph.D. thesis: "Leishmania virulence: from haplotype network to functional genomics"

    Dr. Claretta Bianchi

    2022, Ph.D. thesis: "Catalase: what happened in the evolution of Trypanosomatidae?"

    Dr. Alexandra Zakharova

    2023, Ph.D. thesis: "The inner society of endosymbionts in Leishmaniinae"

    Dr. Amanda Albanaz

    2023, Ph.D. thesis: "Comparative genomics of Trypanosomatidae: from model organisms to outliers"

    Lab alumni, MSc. students

    Mgr. Lucie Kortišová, 2015

    Mgr. Dalibor Váhala, 2015

    Mgr. Denisa Mlacovská, 2017

    Mgr. Adriana Volná, 2017

    Mgr. Martin Kovačik, 2018

    Mgr. Alena Dembitskaya, 2019

    Mgr. Sabina Kühnelová, 2019 (supervised by Dr. Alexei Kostygov)

    Mgr. Sandra Warmusová, 2022

    Mgr. Adam Krayzel, 2023 (supervised by Dr. Natalya Kraeva)